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Displaying results 2791 - 2800 of 10000 in total
  1. Drug

    Sotagliflozin

    go.drugbank.com/drugs/DB12713
    ApprovedInvestigational

    [L39705] Its potency in inhibiting SGLT2 is similar to that of other SGLT2 inhibitors, such as [canagliflozin] and [dapagliflozin], but its potency in inhibiting SGLT1 is >10-fold higher than its predecessors … 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m<sup>2</sup>.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  2. Drug

    Elafibranor

    go.drugbank.com/drugs/DB05187
    ApprovedInvestigational

    [L50768] On June 10, 2024, elafibranor was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis (PBC). … Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist [A263833] that works to inhibit bile acid synthesis.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  3. Target

    Ubiquitin-conjugating enzyme E2 T

    go.drugbank.com/bio_entities/BE0019778
    TargetHumans

    In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386) … May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602).

    Synonyms: Cell proliferation-inducing gene 50 protein
  4. Drug

    Pranoprofen

    go.drugbank.com/drugs/DB13514
    Investigational

    Pranoprofen is an anti-inflammatory agent.

    Products: OFTALAR STERIL GOZ DAMLASI 5 ML
  5. Indication

    Lactose Malabsorption

    go.drugbank.com/conditions/DBCOND0056783
    Drugs: Tilactase
    Synonyms: Intolerance to lactose (finding)
  6. Indication

    Trichomonas Vaginalis Infection

    go.drugbank.com/conditions/DBCOND0044722
    Drugs: Diiodohydroxyquinoline · Policresulen · Tinidazole
    Synonyms: Disease due to Trichomonadidae (disorder)
  7. Indication

    Acquired Coagulation Factor Deficiency

    go.drugbank.com/conditions/DBCOND0032166
    Drugs: Coagulation factor X human · Plasma protein fraction (human)
    Synonyms: Deficiency of coagulation factor due to liver disease (disorder), Deficiency of coagulation factor due to vitamin K deficiency (disorder)
  8. Target

    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    go.drugbank.com/bio_entities/BE0004448
    TargetHumans

    GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). … GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242).

    Synonyms: G1 to S phase transition protein 1 homolog
  9. Indication

    Alcohol Problem Drinking

    go.drugbank.com/conditions/DBCOND0132393
    Drugs: Disulfiram
    Synonyms: [X]Mental and behavioral disorders due to use of alcohol: dependence syndrome, [X]Mental and behavioural disorders due to use of alcohol: dependence syndrome
  10. Drug

    Osbond acid

    go.drugbank.com/drugs/DB14088
    Investigational

    Synonyms: 4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid