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Displaying results 281 - 290 of 1342 in total
  1. Drug

    Anakinra

    go.drugbank.com/drugs/DB00026
    ApprovedInvestigational

    This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. … Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues.

    Synonyms: IL-1RA
  2. Drug

    Brexucabtagene autoleucel

    go.drugbank.com/drugs/DB15699
    ApprovedInvestigational

    [L15148] Brexucabtagene autoleucel was granted full approval by the FDA on July 24, 2020 for the treatment of MCL and acute lymphoblastic leukemia (ALL), and is currently available through Kite Pharma

  3. Drug

    Shark liver oil

    go.drugbank.com/drugs/DB11088
    Approved

    Shark oil is extracted from the livers of sharks, which can account for up to 25% of their total body weight. … Shark oil is a rich source of alkylglycerols and squalene, with relatively low amounts of n-3 polyunsaturated fatty acids.

    Mixtures: Mineral Oil, Petrolatum, Phenylephrine Hydrochloride, Shark Liver Oil, Cocoa Butter, Phenylephrine Hydrochloride, Shark Liver OilSynonyms: Shark liver oil
  4. Drug

    Nemolizumab

    go.drugbank.com/drugs/DB15252
    ApprovedInvestigational

    [A264254] By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation. … Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology

  5. Drug

    Ustekinumab

    go.drugbank.com/drugs/DB05679
    ApprovedInvestigational

    Ustekinumab is currently the first and only approved biologic therapy for ulcerative colitis that targets the interleukin (IL)-12 and IL-23 cytokines. … Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses.

  6. Drug

    Andrographolide

    go.drugbank.com/drugs/DB05767
    Investigational

    Andrographolide (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and in...

  7. Drug

    Benralizumab

    go.drugbank.com/drugs/DB12023
    ApprovedInvestigational

    [A31294] It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R, thus blocking signal transduction. … Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils

  8. Indication

    Refractory Acute Lymphoblastic Leukemia (ALL)

    go.drugbank.com/conditions/DBCOND0069492
    Drugs: Clofarabine · Imatinib
    Synonyms: Leukemia Lymphocytic Acute (All) Refractory, Refractory Acute Lymphoblastic Leukemia (ALL)
  9. Indication

    Hypokalemia

    go.drugbank.com/conditions/DBCOND0003942
    Drugs: Amiloride · Potassium · Potassium acetate · Potassium aspartate · Potassium bicarbonate · Potassium chloride +2 more
    Synonyms: All grades Hypokalemia, Hypokalemia (all grades)
  10. Target

    IgG heavy chain

    go.drugbank.com/bio_entities/BE0010027
    TargetCarrier

    Constant region of immunoglobulin (Ig) heavy chains. Igs are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors, which upon binding ...

    Synonyms: Ig gamma-2 chain C region TIL