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Displaying results 2901 - 2910 of 10000 in total
  1. Indication

    Hansen's Disease

    go.drugbank.com/conditions/DBCOND0064479
    Drugs: Brilliant green cation · Dapsone · Ofloxacin · Protionamide
    Synonyms: Infection due to Mycobacterium leprae
  2. Drug

    Norelgestromin

    go.drugbank.com/drugs/DB06713
    ApprovedInvestigational

    [L63816] Combined hormonal contraceptives containing norelgestromin lower the risk of pregnancy primarily by suppressing ovulation.

    Mixtures: EVRA TRANSDERMAL PATCH (6 mg/600 mcg), Gwyn LoCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Flurpiridaz F-18

    go.drugbank.com/drugs/DB18773
    Approved

    [A264519] Flurpiridaz F-18 is an analog of pyridaben, a mitochondrial complex 1 (MC-1) inhibitor.[L51659]

    Synonyms: 2-tert-butyl-4-chloro-5-((4-((2-(18f)fluoroethoxy)methyl)phenyl)methoxy)pyridazin-3(2h)-one, 2-tert-butyl-4-chloro-5-[[4-(2-(18F)fluoranylethoxymethyl)phenyl]methoxy]pyridazin-3-one
  4. Drug

    (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE

    go.drugbank.com/drugs/DB06888
    Experimental

    Synonyms: (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE
  5. Drug

    Kappadione

    go.drugbank.com/drugs/DB09332
    Approved

    Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is … It has been found to have carcinogenic potential in mammalian cells as well as cytotoxic properties [L1544].

  6. Target

    Baculoviral IAP repeat-containing protein 7

    go.drugbank.com/bio_entities/BE0010707
    TargetHumans

    As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033 … May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033).

    Synonyms: RING finger protein 50
  7. Drug

    Pralsetinib

    go.drugbank.com/drugs/DB15822
    ApprovedInvestigational

    Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. … It is currently marketed under the brand name GAVRETO™ by Blueprint Medicines.[L15986]

    Categories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 Substrates
  8. Drug

    Niraparib

    go.drugbank.com/drugs/DB11793
    ApprovedInvestigational

    [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health Canada on June 27, 2019. … [A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ovarian, fallopian tube, or primary peritoneal cancer.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers
  9. Drug

    Teclistamab

    go.drugbank.com/drugs/DB16655
    ApprovedInvestigational

    cells to promote T cell–mediated cytotoxicity. … [A253587] Teclistamab consists of an anti-BCMA arm and an anti-CD3 arm connected via two interchain disulfide bonds,[A253587, L43622] allowing the drug to recruit CD3-expressing T cells to BCMA-expressing

    Categories: Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager
  10. Indication

    Immune Thrombocytopenia (ITP)

    go.drugbank.com/conditions/DBCOND0035132
    Drugs: Azathioprine · Cortisone acetate · Cyclosporine · Dexamethasone · Hydrocortisone · Hydrocortisone succinate +6 more
    Synonyms: Thrombocytopenia due to immune destruction, Thrombocytopenia due to immune destruction, NOS