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Evolocumab
go.drugbank.com/drugs/DB09303ApprovedInvestigationalEvolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood. … It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies.
Categories: Amino Acids, Peptides, and ProteinsProducts: REPATHA® 140 MG/ML, REPATHA 140 MG/ML SC ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADETTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Serotonin 5-HT3 Receptor Antagonists, Alimentary Tract and MetabolismProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - AmpullenInterleukin-10
go.drugbank.com/bio_entities/BE0002484TargetHumansMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...
Polypeptides: Interleukin-10Synonyms: IL-10Aquaporin-10
go.drugbank.com/bio_entities/BE0018706TransporterHumansAquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...
Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10Clemastine
go.drugbank.com/drugs/DB00283ApprovedInvestigationalAn ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Synonyms: (+)-(2R)-2-(2-(((R)-p-chloro-α-methyl-α-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine, (+)-(2R)-2-[2-[[(R)-p-chloro-α-methyl-α-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidineInternational brands: Tavist-1, Allerhist-1Olaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigationalOlaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2. … [L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell
Synonyms: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-oneCategories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingDeferoxamine
go.drugbank.com/drugs/DB00746ApprovedInvestigationalIt forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Synonyms: Deferrioxamine BCategories: Compounds used in a research, industrial, or household settingErenumab
go.drugbank.com/drugs/DB14039ApprovedInvestigationalErenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines … It is composed of 2 heavy chains, each containing 456 amino acids, and 2 light chains of the lambda subclass, each containing 216 amino acids, with an approximate molecular weight of 150 kDa [FDA Label
Categories: Amino Acids, Peptides, and ProteinsProducts: PASURTA® 140 MG /ML, KUZELVA 70 MG ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETLicaminlimab
go.drugbank.com/drugs/DB18936InvestigationalLicaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease).
Synonyms: immunoglobulin scFv, anti-[Homo sapiens TNF (tumor necrosis factor, TNFSF2, DIF, TNF-alpha)], humanized monoclonal antibody single chain; IG scFv humanized single chain (V-KAPPA-VH) (1-254) [V-KAPPA (Homo, sapiens IGKV1-5*03 (79.2%) -(IGHD) -IGKJ2*02 (77.Allopurinol
go.drugbank.com/drugs/DB00437ApprovedInvestigationalAllopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout [A36705 … Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942].
Synonyms: 1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidineCategories: Cytochrome P-450 CYP1A2 Inhibitors, Heterocyclic Compounds, 2-Ring