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Metamfetamine
go.drugbank.com/drugs/DB01577ApprovedIllicitInvestigationalWithdrawnMethamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. … It is a scheduled drug in most countries due to its high potential for addiction and abuse.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesLumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigationalCystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, a transmembrane ion … Consequently, lumacaftor increases successful production of CFTR ion channels and the total number of receptors available for use at the cell membrane for fluid and ion transport.
Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inducersPhenindamine
go.drugbank.com/drugs/DB01619ApprovedAntihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. … Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body.
Categories: Antihistamines for Systemic UsePF-04447943
go.drugbank.com/drugs/DB11953InvestigationalPF-04447943 has been investigated for the treatment of Alzheimer's Disease.
PF-00446687
go.drugbank.com/drugs/DB12517InvestigationalPF-00446687 has been investigated for the treatment of Erectile Dysfunction.
Categories: Receptor, Melanocortin, Type 4, agonistsTegafur
go.drugbank.com/drugs/DB09256ApprovedInvestigationalTegafur is usually given in combination with other drugs that enhance the bioavailability of the 5-FU by blocking the enzyme responsible for its degradation, or serves to limit the toxicity of 5-FU by … Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesInternational brands: ESUEEW AN TChlorcyclizine
go.drugbank.com/drugs/DB08936ApprovedChlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Categories: Antihistamines for Systemic UseClevidipine
go.drugbank.com/drugs/DB04920ApprovedInvestigationalClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 SubstratesProducts: Cleviprex 0,5 mg/ml Emulsion zur InjektionMechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Chemical Warfare AgentsAmifampridine
go.drugbank.com/drugs/DB11640ApprovedAmifampridine phosphate is a more stable salt that serves as an active ingredient of EMA-approved Firdapse, which was previously marketed as Zenas. … Patients with LEMS develop serum antibodies against presynaptic P/Q-type voltage-gated calcium channels, leading to decreased presynaptic calcium levels and reduced quantal release of acetylcholine, which