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PF-00446687
go.drugbank.com/drugs/DB12517InvestigationalPF-00446687 has been investigated for the treatment of Erectile Dysfunction.
Categories: Receptor, Melanocortin, Type 4, agonistsTegafur
go.drugbank.com/drugs/DB09256ApprovedInvestigationalTegafur is usually given in combination with other drugs that enhance the bioavailability of the 5-FU by blocking the enzyme responsible for its degradation, or serves to limit the toxicity of 5-FU by … Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers.
International brands: ESUEEW AN TCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesClevidipine
go.drugbank.com/drugs/DB04920ApprovedInvestigationalClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 SubstratesProducts: Cleviprex 0,5 mg/ml Emulsion zur InjektionMechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL … A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas.
Categories: Chemical Warfare AgentsPhenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalIt promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Mixtures: PB Hyos, Re-PB HyosCategories: P-glycoprotein inducers, P-glycoprotein substratesTetracaine
go.drugbank.com/drugs/DB09085ApprovedInvestigationalVet approvedTetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Synonyms: 2-(Dimethylamino)ethyl p-(butylamino)benzoate, p-Butylaminobenzoyl-2-dimethylaminoethanolCategories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use, Anesthetics for Topical UseBexarotene
go.drugbank.com/drugs/DB00307ApprovedInvestigationalBexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Synonyms: p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acidCategories: Retinoids for cancer treatment, Cytochrome P-450 SubstratesAgomelatine
go.drugbank.com/drugs/DB06594ApprovedInvestigationalAgomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. … The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesCopper oxodotreotide Cu-64
go.drugbank.com/drugs/DB15873Approved[A220348] In a head-to-head trial, the former tracer detected twice as many lesions as the latter.[A220348] … Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over <sup>68</sup>Ga-labeled somatostatin analogs for positron emission tomography (PET).
Difamilast
go.drugbank.com/drugs/DB14987ApprovedInvestigational[L56052, A275420] This skin disease occurs most frequently in children and can have an onset as early as within the first 2 years of life. … The drug is indicated for the topical treatment of mild to moderate atopic dermatitis in adults and pediatric patients 2 years of age and older [L55042]. It is approved in Japan and the United States.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers