Search
Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway
smpdb.ca/view/SMP0126450Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … The receptors that are being stimulated are 5-HT 2A, 2B, and 2C serotonin receptors and alpha 1 and beta 1 adrenergic receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporterMethylphenidate Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126572Drug actionMethylphenidate binds and blocks the sodium-dependent noradrenaline transporter which prevents the synaptic norepinephrine from re-entering the presynaptic neuron. … Norepinephrine is then transported to the prefrontal cortex and released into the synapse when the neuron is stimulated and fires.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Methylphenidate +7 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Sodium-dependent noradrenaline transporterTyrosine Metabolism
smpdb.ca/view/SMP0000006MetabolicAcetoacetate is a ketone body, which is activated with succinyl-CoA, and thereafter it can be converted into acetyl-CoA, which in turn can be oxidized by the citric acid cycle (also known as the TCA cycle … The accumulation of excess homogentisic acid and its oxide (named alkapton) in the urine of afflicted individuals can lead to a condition known as alkaptonuria.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseTyrosinemia Type I
smpdb.ca/view/SMP0000218DiseaseThe lack of this enzyme's function leads to a buildup of 4-fumarylacetoacetic acid as it couldn't be broken down to fumaric acid and acetoacetic acid. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseMonoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0000533DiseaseWith the inactivation of MAO-A, 3-methoxytyramine builds up as there are no reactions that use it, and both of these paths lead to a decrease in the concentration of homovanillic acid, as there are no … and other effects.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseHawkinsinuria
smpdb.ca/view/SMP0125590Diseasepyroglutamic acid in urine; and L-tyrosine in plasma. … A deficiency in this enzyme results in accumulation of hawkinsin in urine and plasma; cis-4-hydroxycyclohexylacetic acid, trans-4-hydroxycyclohexylaceid, vanillactic acid, 4-hydroxyphenylpyruvic acid,
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseTyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0000494DiseaseThe enzymatic basis of neonatal tyrosinemia is complex and involves the susceptibility of p-hydroxyphenylpyruvic acid oxidase to inhibition in the presence of its substrate, p-hydroxyphenylpyruvic acid … The inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseAlkaptonuria
smpdb.ca/view/SMP0000169DiseaseA mutation in this enzyme results in accumulation of homogentisic acid in urine. Symptoms, which present in adulthood, include arthritis, black or brown urine, and urolithiasis. … Alkaptonuria (Homogentisic acid oxidase deficiency) is an autosomal recessive disease caused by a mutation in the HGD gene which codes for homogentisate 1,2-dioxygenase.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseHawkinsinuria
smpdb.ca/view/SMP0000190Diseasepyroglutamic acid in urine; and L-tyrosine in plasma. … A deficiency in this enzyme results in accumulation of hawkinsin in urine and plasma; cis-4-hydroxycyclohexylacetic acid, trans-4-hydroxycyclohexylaceid, vanillactic acid, 4-hydroxyphenylpyruvic acid,
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseTyrosinemia Type I
smpdb.ca/view/SMP0125591DiseaseThe lack of this enzyme's function leads to a buildup of 4-fumarylacetoacetic acid as it couldn't be broken down to fumaric acid and acetoacetic acid. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylase