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Fluoxetine Action Pathway
smpdb.ca/view/SMP0000426Drug actionIt does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterNicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionThis causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. … Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterCodeine Action Pathway
smpdb.ca/view/SMP0000405Drug actionOpiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. … This results in hyperpolarization and reduced neuronal excitability.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterOxymorphone Action Pathway
smpdb.ca/view/SMP0000412Drug actionThe binding of oxymorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterCarfentanil Action Pathway
smpdb.ca/view/SMP0000414Drug actionThe binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterRemifentanil Action Pathway
smpdb.ca/view/SMP0000416Drug actionand decrease in cAMP production. … Analgesia, anesthesia, and respiratory depression are a function of remifentanial’s action on these mu-type opioid receptors.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterTramadol Action Action Pathway
smpdb.ca/view/SMP0000671Drug actionTramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDiphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionThe binding of diphenoxylate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterLevomethadyl Acetate Action Action Pathway
smpdb.ca/view/SMP0000677Drug actionHowever, levomethadyl acetate is more active and more toxic than morphine. … The binding of levomethadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter3-Methylthiofentanyl Action Pathway
smpdb.ca/view/SMP0000679Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter