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Displaying results 21 - 30 of 2572 in total
  1. Pathway

    Metabolism and Physiological Effects of S-Adenosylhomocysteine

    smpdb.ca/view/SMP0127690
    Metabolic

    S-Adenosyl-L-homocysteine (SAH) is formed by the demethylation of S-adenosyl-L-methionine. … S-Adenosyl-L-homocysteine is a potent inhibitor of S-adenosyl-L-methionine-dependent methylation reactions. It is toxic to immature lymphocytes and can lead to immunosuppression.

    Drugs: Ademetionine · Methionine · ATP · Potassium cation · Magnesium cation · Pyrophosphoric acid
    Enzymes: Methionine adenosyltransferase 2 subunit beta
  2. Pathway

    Sarcosine Oncometabolite Pathway

    smpdb.ca/view/SMP0002313
    Disease

    consisting of S-adenosylmethionine synthase and methionine adenosyltransferase. … A separate set of reactions outside of the mitochondria begins with the L-methionine produced by betaine—homocysteine S-methyltransferase 1, which is then converted to S-adenosylmethionine by a complex

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Serine · Methionine +10 more
    Enzymes: Methionine adenosyltransferase 2 subunit beta
  3. Pathway

    Metabolism and Physiological Effects of Dimethylglycine

    smpdb.ca/view/SMP0124873
    Metabolic

    Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into glycine. Cho...

    Drugs: Choline · Methionine · NADH · Zinc · N,N-dimethylglycine · Flavin adenine dinucleotide +1 more
  4. Pathway

    Sarcosinemia

    smpdb.ca/view/SMP0125579
    Disease

    This, along with homocysteine, react using betaine-homocysteine S-methyltransferase to form L-methionine, as well as dimethylglycine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  5. Pathway

    Sarcosinemia

    smpdb.ca/view/SMP0000244
    Disease

    This, along with homocysteine, react using betaine-homocysteine S-methyltransferase to form L-methionine, as well as dimethylglycine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  6. Pathway

    Non-Ketotic Hyperglycinemia

    smpdb.ca/view/SMP0000223
    Disease

    Non Ketotic Hyperglycinemeia (Glycine encephalopathy; Glycine cleavage system deficiency; NKH) is caused by mutations in several genes in the mitochondrial glycine cleavage system. These include the genes encoding P protein (GLDC), T pro...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  7. Pathway

    3-Phosphoglycerate Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000721
    Disease

    3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  8. Pathway

    Dimethylglycine Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000484
    Disease

    Dimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  9. Pathway

    Dimethylglycine Dehydrogenase Deficiency

    smpdb.ca/view/SMP0125578
    Disease

    Dimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  10. Pathway

    Non-Ketotic Hyperglycinemia

    smpdb.ca/view/SMP0125580
    Disease

    Non Ketotic Hyperglycinemeia (Glycine encephalopathy; Glycine cleavage system deficiency; NKH) is caused by mutations in several genes in the mitochondrial glycine cleavage system. These include the genes encoding P protein (GLDC), T pro...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more