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Displaying results 21 - 30 of 45 in total
  1. Pathway

    Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)

    smpdb.ca/view/SMP0125771
    Disease

    Pyruvate Decarboxylase E1 Component Deficiency is caused by a defect in the PDHA1 gene which codes for mitochondrial pyruvate dehydrogenase E1 component subunit alpha, somatic form. This is a homotetrameric enzyme that catalyses the deca...

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
  2. Pathway

    Pyruvate Kinase Deficiency

    smpdb.ca/view/SMP0125774
    Disease

    Pyruvate kinase deficiency is a genetic disorder. It affects red blood cells in the body. Patients are affected by a condition called chronic hemolytic anemia, which is where red blood cells undergo hemolysis before they are meant to whi...

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
  3. Pathway

    Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)

    smpdb.ca/view/SMP0000334
    Disease

    Pyruvate Decarboxylase E1 Component Deficiency is caused by a defect in the PDHA1 gene which codes for mitochondrial pyruvate dehydrogenase E1 component subunit alpha, somatic form. This is a homotetrameric enzyme that catalyses the deca...

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
  4. Pathway

    Leigh Syndrome

    smpdb.ca/view/SMP0125770
    Disease

    Leigh Syndrome, also called Leigh Disease or infantile subacute necrotizing encephalopathy, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder that is caused by a mutation of any one of 75 different genes. Disrup...

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
  5. Pathway

    Primary Hyperoxaluria II, PH2

    smpdb.ca/view/SMP0125773
    Disease

    Primary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal diseas...

    Drugs: Pyruvic acid · Biotin · Adenosine phosphate · Glutathione · NADH · ATP +13 more
  6. Drug

    Mephenesin

    go.drugbank.com/drugs/DB13583
    ApprovedWithdrawn

    Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression . It first entered use in the 1950s.

    Categories: Propylene Glycols, Glycols
  7. Indication

    Dry Eyes

    go.drugbank.com/conditions/DBCOND0054254
    Drugs: Acrylic Acid · Carbomer · Carbomer homopolymer type C · Carbopol 974P · Carboxymethylcellulose · Chamomile +12 more
  8. Drug

    Lodoxamide

    go.drugbank.com/drugs/DB06794
    Approved

    Lodoxamide is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. Thes...

    Categories: Propylene Glycols, Glycols
  9. Drug

    Poloxalene

    go.drugbank.com/drugs/DB11451
    InvestigationalVet approved

    Ethylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides.

    Categories: Glycols, Ethylene Glycols
  10. Drug

    Pentaerythritol tetranitrate

    go.drugbank.com/drugs/DB06154
    ApprovedWithdrawn

    Pentaerythritol tetranitrate is the nitrate ester of pentaerythritol that possesses explosive properties. When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in...

    Categories: Propylene Glycols, Glycols