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Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway
smpdb.ca/view/SMP0125166Drug actionNorepinephrine is a sympathomimetic that is regularly found to be the primary neurotransmitter in postganglionic neurons.
Droxidopa A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126494Drug actionDroxidopa is an orally active synthetic precursor of norepinephrine that increases the deficient supply of norepinephrine in patients with NOH, thereby improving orthostatic blood pressure and alleviating … Norepinephrine activates the alpha-1 adrenergic receptor which activates the Gq protein cascade.
Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126078Drug actionNorepinephrine is stored in synaptic storage sites where norepinephrine was already being stored. When the neuron is depolarized, this accumulation of norepinephrine is released into the synapse. … Through the beta-1 adrenergic receptor, the heart is stimulated by norepinephrine.
Neuron Function
smpdb.ca/view/SMP0000224PhysiologicalThe action potential travels along the axon and upon reaching the end, causes neurotransmitters such as serotonin, dopamine, or norepinephrine to be released into the synapse.
Tramadol Action Action Pathway
smpdb.ca/view/SMP0000671Drug action. (+)-Tramadol is a selective agonist of the mu receptor (OP3) inhibiting serotonin reuptake, while (-)-Tramadol inhibits norepinephrine reuptake in the central nervous system.
Desipramine Action Pathway
smpdb.ca/view/SMP0000423Drug actionHigher concentrations of norepinephrine and serotonin have also been shown to have long-term neuromodulatory effects. … Desipramine is a tricyclic antidepressant that exerts its therapeutic effects by inhibiting norepinephrine and serotonin reuptake in the brain.
Cocaine Action Pathway
smpdb.ca/view/SMP0000395Drug actionCocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and...
Dibucaine Action Pathway
smpdb.ca/view/SMP0000396Drug actionDibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...
Levobupivacaine Action Pathway
smpdb.ca/view/SMP0000397Drug actionLevobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Levobupivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it i...
Oxybuprocaine Action Pathway
smpdb.ca/view/SMP0000400Drug actionOxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Oxybuprocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is pr...