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Displaying results 21 - 30 of 224 in total
  1. Pathway

    Prochlorperazine - Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126629
    Drug action

    Prochlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. … Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 more
  2. Target

    Malate dehydrogenase

    go.drugbank.com/bio_entities/BE0000056
    TargetEscherichia coli (strain K12)

    Catalyzes the reversible oxidation of malate to oxaloacetate.

    Polypeptides: Malate dehydrogenaseFunction: L-malate dehydrogenase activity
  3. Target

    Malate dehydrogenase

    go.drugbank.com/bio_entities/BE0001891
    TargetAquaspirillum arcticum

    Catalyzes the reversible oxidation of malate to oxaloacetate.

    Polypeptides: Malate dehydrogenaseFunction: L-malate dehydrogenase activity
  4. Pathway

    Magnesium malate Drug Metabolism

    smpdb.ca/view/SMP0130544
    Metabolic

    Magnesium malate passes through the liver and is then excreted from the body mainly through the kidney. … Magnesium malate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Magnesium malate
  5. Drug

    Fluvoxamine

    go.drugbank.com/drugs/DB00176
    ApprovedInvestigational

    Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine...

    Salts: Fluvoxamine maleateProducts: Fluvoxamine maleate, Fluvoxamine Maleate
  6. Pathway

    Prochlorperazine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126604
    Drug action

    Prochlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. … Dopamine-antagonizing medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 more
  7. Drug

    Carbinoxamine

    go.drugbank.com/drugs/DB00748
    Approved

    Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on b...

    Salts: Carbinoxamine maleateProducts: Carbinoxamine Maleate, Carbinoxamine Maleate Extended-Release Oral Suspension
  8. Drug

    Avatrombopag

    go.drugbank.com/drugs/DB11995
    ApprovedInvestigational

    [L2931] It is administered orally as the salt form avatrombopag maleate.

    Salts: Avatrombopag maleateProducts: Avatrombopag Maleate
  9. Target

    Malate dehydrogenase, cytoplasmic

    go.drugbank.com/bio_entities/BE0000589
    TargetHumans

    Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237).

    Polypeptides: Malate dehydrogenase, cytoplasmicSynonyms: Cytosolic malate dehydrogenase
  10. Target

    Malate dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000780
    TargetEnzymeHumans

    Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor (PubMed:27989324). … Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic

    Polypeptides: Malate dehydrogenase, mitochondrial