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Displaying results 291 - 300 of 10000 in total
  1. Indication

    NYHA Class I Congestive Heart Failure

    go.drugbank.com/conditions/DBCOND0025304
    Drugs: Perindopril
    Synonyms: Heart failure NYHA class I, NYHA Class I Congestive Heart Failure
  2. Drug

    Pyridoxine

    go.drugbank.com/drugs/DB00165
    ApprovedInvestigationalNutraceuticalVet approved

    More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids … Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods.

    Synonyms: Vitamin B 6, 3-hydroxy-4,5-dimethylol-α-picolineMixtures: Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA, O-Cal Prenatal Vitamin
  3. Target

    Antiviral innate immune response receptor RIG-I

    go.drugbank.com/bio_entities/BE0012418
    TargetHumans

    Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). … Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624

    Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I, RNA sensor RIG-I
  4. Target

    High affinity immunoglobulin gamma Fc receptor I

    go.drugbank.com/bio_entities/BE0000710
    TargetCarrierHumans

    High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-i...

    Polypeptides: High affinity immunoglobulin gamma Fc receptor ISynonyms: IgG Fc receptor I
  5. Target

    DNA-directed RNA polymerase I subunit RPA49

    go.drugbank.com/bio_entities/BE0019377
    TargetHumans

    Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025 … Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024)

    Polypeptides: DNA-directed RNA polymerase I subunit RPA49Synonyms: RNA polymerase I subunit A49, DNA-directed RNA polymerase I subunit E
  6. Target

    DNA-directed RNA polymerase I subunit RPA2

    go.drugbank.com/bio_entities/BE0019741
    TargetHumans

    Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. … Forms Pol I active center together with the largest subunit POLR1A/RPA1.

    Polypeptides: DNA-directed RNA polymerase I subunit RPA2Synonyms: RNA polymerase I subunit 2, DNA-directed RNA polymerase I 135 kDa polypeptide
  7. Drug

    Witch hazel

    go.drugbank.com/drugs/DB11111
    ApprovedInvestigationalNutraceutical

    Mixtures: Bottoms Up Health, Preparation HProducts: Leaders Daily Wonders You Say Dry I Say No More, Tension No. 5
  8. Drug

    alpha-Tocopherol succinate

    go.drugbank.com/drugs/DB14001
    ApprovedNutraceuticalVet approved

    Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. … This biologic action of vitamin E consequently continues to generate ongoing interest and study in whether or not its antioxidant abilities may be used to help assist in preventing or treating a number

    Mixtures: Henkel's Vitamin E and Selenium Cap, Revit Plus CapCategories: Compounds used in a research, industrial, or household setting, Vitamin E
  9. Drug

    Potassium bicarbonate

    go.drugbank.com/drugs/DB11098
    ApprovedInvestigational

    Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. … It is used in medicine as an antacid.[T141] It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids.

    Mixtures: Neo K, Buffered Vitamin C Pwr W Cal-mag-potassiumProducts: Klor-con/ef, KLOR-Con/EF
  10. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … [L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide

    Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: YARDIX® 240MG, TECFIDERA® 240MG