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Cyclin-dependent kinase 7
go.drugbank.com/bio_entities/BE0001913TargetHumansCatalytic subunit of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). … Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from
Synonyms: TFIIH basal transcription factor complex kinase subunitHeat shock 70 kDa protein 13
go.drugbank.com/bio_entities/BE0008957TargetHumansHas peptide-independent ATPase activity
Synonyms: Microsomal stress-70 protein ATPase coreRunt-related transcription factor 1
go.drugbank.com/bio_entities/BE0010423TargetHumansForms the heterodimeric complex core-binding factor (CBF) with CBFB. … RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their
Synonyms: Core-binding factor subunit alpha-2, SL3/AKV core-binding factor alpha B subunitProtein S100-A8
go.drugbank.com/bio_entities/BE0008955TargetHumansActivates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme … The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL
Synonyms: Leukocyte L1 complex light chainBaculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansProtects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
Synonyms: TNFR2-TRAF-signaling complex protein 2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Complex I-B16.6Baculoviral IAP repeat-containing protein 3
go.drugbank.com/bio_entities/BE0010674TargetHumansProtects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
Synonyms: TNFR2-TRAF-signaling complex protein 1RuvB-like 2
go.drugbank.com/bio_entities/BE0009019TargetHumansProposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910 … May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026)
Synonyms: INO80 complex subunit JRetinol dehydrogenase 11
go.drugbank.com/bio_entities/BE0002321TargetHumansRetinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low redu...
Synonyms: HCV core-binding protein HCBP12Cyclin-dependent kinases
go.drugbank.com/bio_entities/BE0010231TargetHumansComponent of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex … Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules
Synonyms: Mediator complex subunit CDK8, Tat-associated kinase complex catalytic subunit