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Immunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.
Synonyms: Joining chain of multimeric IgA and IgMAuranofin
go.drugbank.com/drugs/DB00995ApprovedInvestigationalHeme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties. … Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity.
Categories: Antiinflammatory and Antirheumatic ProductsNuclear cap-binding protein subunit 2
go.drugbank.com/bio_entities/BE0013483TargetHumansIn the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding … The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858)
Polypeptides: Nuclear cap-binding protein subunit 2Synonyms: 20 kDa nuclear cap-binding proteinNuclear cap-binding protein subunit 1
go.drugbank.com/bio_entities/BE0014101TargetHumansIn the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity … The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound
Polypeptides: Nuclear cap-binding protein subunit 1Synonyms: 80 kDa nuclear cap-binding proteinImelasomeran
go.drugbank.com/drugs/DB17090ApprovedInvestigationalImelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 mRNA vaccine. … [L45320] It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly infectious variant of concern first documented in 2021.[L43922]
TrenibotulinumtoxinE
go.drugbank.com/drugs/DB19082Approved[L64095] It blocks neuromuscular transmission by cleaving SNAP-25, producing partial chemical denervation and a localized reduction in muscle activity. … [L64095] TrenibotulinumtoxinE was approved by Health Canada in June 2026[L64128] and by the European Commission on July 17, 2026, with the decision applying across all 30 European Economic Area countries
Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsTolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Categories: Drugs Used in Diabetes, Alimentary Tract and MetabolismSynonyms: N-(p-Toluenesulfonyl)-N'-hexamethyleniminoureaClotiazepam
go.drugbank.com/drugs/DB01559ApprovedIllicitClotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
Categories: Benzodiazepines and benzodiazepine derivativesInflammatory Muscle Disease
go.drugbank.com/conditions/DBCOND0155571Synonyms: Other inflammatory and immune myopathies, not elsewhere classifiedOsteoarthritis of the Knee
go.drugbank.com/conditions/DBCOND0032623Synonyms: Osteoarthritis and allied disorders, Osteoarthritis in the Knee