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Polythiazide
go.drugbank.com/drugs/DB01324ApprovedA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Categories: polythiazide and potassium, Genito Urinary System and Sex HormonesAlemtuzumab
go.drugbank.com/drugs/DB00087ApprovedInvestigationalThe Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). … [L43397] Alemtuzumab was approved by the FDA in 2001.[L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic lymphocytic leukemia (B-CLL).
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsDiffuse Large B-Cell Lymphoma (DLBCL)
go.drugbank.com/conditions/DBCOND0028221Synonyms: Malignant lymphoma, large cell, cleaved and noncleaved, Malignant lymphoma - large cell cleaved and non-cleavedAC-100
go.drugbank.com/drugs/DB05671InvestigationalAC-100 is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells (a fragment from matrix extracellular phosphoglycoprotein). … It is being developed by Acologix, Inc.
Vestronidase alfa
go.drugbank.com/drugs/DB12366ApprovedInvestigationalIn clinical trials, vestronidase alfa treatment demonstrated improvement and stabilization in motor symptoms by increasing the patients' ability to walk longer distances in comparison to treatment with … which can lead to lung infections and trouble breathing.
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismAmino acid transporter heavy chain SLC3A1
go.drugbank.com/bio_entities/BE0001130TransporterHumansSLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity … SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids.
Synonyms: Neutral and basic amino acid transport proteinSerine/threonine-protein kinase 26
go.drugbank.com/bio_entities/BE0004109TargetHumansPart of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. … STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling.
Synonyms: MST3 and SOK1-related kinaseCytohesin-3
go.drugbank.com/bio_entities/BE0004433TargetHumansPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)
Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3Anoctamin-1
go.drugbank.com/bio_entities/BE0004746TargetHumansActs as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. … Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825).
Synonyms: Tumor-amplified and overexpressed sequence 2Diphenylguanidine
go.drugbank.com/drugs/DB14191ApprovedDiphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. … It is also a dermatological sensitizer and allergen. Sensitivity to diphenylguanidine may be identified with a clinical patch test.