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Clobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining … [A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit,
Categories: GABA-A Receptor Agonists, P-glycoprotein substratesVinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalVinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the trea...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsGrepafloxacin
go.drugbank.com/drugs/DB00365ApprovedWithdrawnGrepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for card...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTriamterene
go.drugbank.com/drugs/DB00384ApprovedTriamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the d...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in sm...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesBeclomethasone dipropionate
go.drugbank.com/drugs/DB00394ApprovedInvestigationalBeclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is rapidly converted into 17-BMP upon administration. … [L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action.
Categories: Corticosteroid Hormone Receptor Agonists, P-glycoprotein inducersAcetohexamide
go.drugbank.com/drugs/DB00414ApprovedWithdrawnA sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Synonyms: 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea, N-(p-Acetylphenylsulfonyl)-N'-cyclohexylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesCerivastatin
go.drugbank.com/drugs/DB00439ApprovedWithdrawnOn August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this chol...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2B6 InducersCelecoxib
go.drugbank.com/drugs/DB00482ApprovedInvestigationalCelecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptom...
Synonyms: p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamideCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMethoxsalen
go.drugbank.com/drugs/DB00553ApprovedInvestigationalA naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 Inhibitors