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5'-AMP-activated protein kinase catalytic subunit alpha-1
go.drugbank.com/bio_entities/BE0000677TargetHumansCatalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:31492851, PubMed:37821951...
Polypeptides: 5'-AMP-activated protein kinase catalytic subunit alpha-1tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase
go.drugbank.com/bio_entities/BE0002518TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
Polypeptides: tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferaseHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
go.drugbank.com/bio_entities/BE0003134TargetHumansSpecifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity...
Polypeptides: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AFunction: 3',5'-cyclic-AMP phosphodiesterase activityLeucine-rich repeat-containing G protein-coupled receptor 5
go.drugbank.com/bio_entities/BE0010835TargetHumansReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with ph...
Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5Transient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansMonovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated di...
Polypeptides: Transient receptor potential cation channel subfamily M member 5Synonyms: LTrpC-5, Long transient receptor potential channel 5Pravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalPravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. … [L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained.
Synonyms: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acidMixtures: PRAVAFEN® CAPSULASValaciclovir
go.drugbank.com/drugs/DB00577ApprovedInvestigationalIt was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline [L5671]. Valacyclovir is the L-valine ester of aciclovir. … Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades.
Synonyms: L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester, L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanineCategories: Heterocyclic Compounds, 2-RingCaffeine
go.drugbank.com/drugs/DB00201ApprovedInvestigational[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. … [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.
Synonyms: 1-methyltheobromine, 7-methyltheophyllineMixtures: ACETAMINOFEN 500 MG.. CLORFENIRAMINA MALEATO 2 MG. Y CAFEINA ANHIDRA 5 MG. GRANULADO PARA RECONSTITUIR SABOR LIMON- MIEL., Re-action EGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationaltreatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe … Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate
Products: Simponi Solution for Injection in Pre-filled Syringe 50 mg/0.5 ml, SIMPONI 50 MGHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigational[A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications. … [T691] Hydralazine hydrochloride was FDA approved on 15 January 1953.[L8779]
Synonyms: 6-Hydralazine, 1-HydrazinophthalazineInternational brands: Cesoline W, Cesoline Y