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Displaying results 3141 - 3150 of 10000 in total
  1. Drug

    Afelimomab

    go.drugbank.com/drugs/DB04956
    Experimental

    Afelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis.

  2. Pathway

    Acebutolol Action Pathway

    smpdb.ca/view/SMP0000296
    Drug action

    Acebutolol (also known as Sectral or Prent) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats (arrhythmias). Acebutolol al...

    Drugs: ATP · Acebutolol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  3. Pathway

    Penbutolol Action Pathway

    smpdb.ca/view/SMP0000305
    Drug action

    Penbutolol (also known as Levatol or Levatolol) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Penbutolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the b...

    Drugs: ATP · Potassium cation · Penbutolol · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  4. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    As a result, other related drugs with longer half-lives, such as mexiletine and tocainide, were developed. … During rest, or diastole, cells maintain a negative membrane potential; i.e. the inside the cell is negatively charged relative to the cells’ extracellular environment.

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  5. Pathway

    Mexiletine Action Pathway

    smpdb.ca/view/SMP0000329
    Drug action

    Mexiletine may be used to treat ventricular arrhythmias. … During rest, or diastole, cells maintain a negative membrane potential; i.e. the inside the cell is negatively charged relative to the cells’ extracellular environment.

    Drugs: ATP · Mexiletine · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  6. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0000367
    Drug action

    This effect may prevent free radical damage to treat chronic heart failure.

    Drugs: ATP · Carvedilol · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  7. Pathway

    Amlodipine Action Pathway

    smpdb.ca/view/SMP0000376
    Drug action

    Amlodipine, trade name Norvasc, is a dihydropyridine calcium channel blocker (CCB) prescribed to treat hypertension and exertion-related angina. The drug acts directly on vascular smooth muscle to cause peripheral vasodilation. Amlodipin...

    Drugs: ATP · Amlodipine · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  8. Pathway

    Nitrendipine Action Pathway

    smpdb.ca/view/SMP0000382
    Drug action

    Nitrendipine (also known as Bayotensin or Nidrel) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension.

    Drugs: ATP · Nitrendipine · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  9. Pathway

    Striated Muscle Contraction

    smpdb.ca/view/SMP0000588
    Physiological

    Each individual myofibril consists of many repeating units called sarcomeres. … Numerous actin filaments being pulled together simultaneously across many muscles cells triggers muscle contraction.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  10. Pathway

    Bupranolol Action Pathway

    smpdb.ca/view/SMP0000670
    Drug action

    Bupranolol is a nonselective beta-blocker with structural similarity to propanolol. Both drugs do not have intrinsic sympathomimetic activity. It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibi...

    Drugs: ATP · Potassium cation · Calcium · Bupranolol
    Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase