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Displaying results 311 - 320 of 495 in total
  1. Drug

    Edaravone

    go.drugbank.com/drugs/DB12243
    ApprovedInvestigational

    [L44017] Edaravone was initially granted orphan designation by the European Medicines Agency on June 19, 2015 [L44007] and was under regulatory review in Europe. … However, the drug manufacturer, Mitsubishi Tanabe Pharma, withdrew the Marketing Authorization Application (MAA) for edaravone from the European market on May 24, 2019, in response to the request made

  2. Drug

    Empagliflozin

    go.drugbank.com/drugs/DB09038
    ApprovedInvestigational

    Empagliflozin was further approved by the EMA in March 2022 and Health Canada in April 2022, making it the first and only approved treatment in Europe and Canada for adults with symptomatic chronic heart

  3. Target

    Holliday junction branch migration complex subunit RuvB

    go.drugbank.com/bio_entities/BE0001514
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication … The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.

    Polypeptides: Holliday junction branch migration complex subunit RuvB
  4. Target

    Cytochrome b6-f complex iron-sulfur subunit

    go.drugbank.com/bio_entities/BE0002474
    TargetMastigocladus laminosus

    Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.

    Polypeptides: Cytochrome b6-f complex iron-sulfur subunit
  5. Target

    Cytochrome b-c1 complex subunit Rieske, mitochondrial

    go.drugbank.com/bio_entities/BE0003858
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster.

    Polypeptides: Cytochrome b-c1 complex subunit Rieske, mitochondrialSynonyms: Complex III subunit 5, Cytochrome b-c1 complex subunit 5
  6. Drug

    Loncastuximab tesirine

    go.drugbank.com/drugs/DB16222
    ApprovedInvestigational

    Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to t...

  7. Target

    Major histocompatibility complex class I-related protein 1

    go.drugbank.com/bio_entities/BE0003573
    TargetHumans

    In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1.2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers

    Polypeptides: Major histocompatibility complex class I-related protein 1
  8. Target

    ATP synthase F(1) complex subunit gamma, mitochondrial

    go.drugbank.com/bio_entities/BE0003842
    TargetHumans

    ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). … Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated

    Polypeptides: ATP synthase F(1) complex subunit gamma, mitochondrial
  9. Target

    ATP synthase F(0) complex subunit e, mitochondrial

    go.drugbank.com/bio_entities/BE0009021
    TargetHumans

    Part of the complex F(0) domain (PubMed:37244256) … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).

    Polypeptides: ATP synthase F(0) complex subunit e, mitochondrialFunction: protein-containing complex binding
  10. Target

    Phospholipid-transporting ATPase VA

    go.drugbank.com/bio_entities/BE0011629
    TransporterHumans

    Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane

    Synonyms: ATPVA, P4-ATPase flippase complex alpha subunit ATP10A