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Dosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalThe use of dosulepsin is only recommended in patients who are intolerant or unresponsive to alternative antidepressant therapies. … Its hydrochloride form is a common active ingredient in different drug formulations.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeBafilomycin A1
go.drugbank.com/drugs/DB06733ExperimentalThe bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. … These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).
Tagatose
go.drugbank.com/drugs/DB04936InvestigationalAdditionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes. … It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener.
Categories: Compounds used in a research, industrial, or household settingStreptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen
go.drugbank.com/drugs/DB10294ApprovedInvestigationalThe saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate. … capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 3 individually conjugated to
Mixtures: Prevenar 13 Suspension For InjectionStreptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen
go.drugbank.com/drugs/DB10296ApprovedInvestigationalThe saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate. … capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 6a individually conjugated to
Mixtures: PREVENAR 13 SUSPENSION FOR INJECTIONEtorphine
go.drugbank.com/drugs/DB01497ExperimentalIllicitVet approvedIn certain countries, etorphine is classified as a Schedule 1 drug and hence, in these countries, it can be used legally only by health professionals and for research purposes. … Etorphine is only available to the patients under an official prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds with 4 or More RingsCurcumin
go.drugbank.com/drugs/DB11672ApprovedInvestigationalDue to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell … Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy
Categories: Compounds used in a research, industrial, or household settingSulindac
go.drugbank.com/drugs/DB00605ApprovedInvestigationalSulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. … While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Penbutolol
go.drugbank.com/drugs/DB01359ApprovedInvestigationalWithdrawnThis binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. … Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects.
Benzthiazide
go.drugbank.com/drugs/DB00562ApprovedThiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. … Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics).