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Cyclothiazide
go.drugbank.com/drugs/DB00606ApprovedThis results in an increase in potassium excretion via the sodium-potassium exchange mechanism. … As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water.
Categories: cyclothiazide and potassium, Genito Urinary System and Sex HormonesLNP-nCoVsaRNA Vaccine
go.drugbank.com/drugs/DB15799ExperimentalThe vaccine was developed in and tested by the Medical Research Council Clinical Trials Unit at UCL in the UK, and jointly funded by UK Research and Innovation. … LNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells.
Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15731InvestigationalThe isolated cells are expanded in culture and are able to be used allogenically -- meaning that one donor’s cells can be given to other unrelated patients. … Regarding the modifications of these UC-MSCs, CD362, also known as syndecan-2, is a surface marker identified on MSCs with enhanced clonogenicity and immunomodulatory properties.
Dehydroascorbic acid
go.drugbank.com/drugs/DB08830ExperimentalIn the body, both dehydroascorbic acid and ascorbic acid have similar biological activity as antivirals but dehydroascorbic acid also has neuroprotective effects. … Dehydroascorbic acid is made from the oxidation of ascorbic acid. This reaction is reversible, but dehydroascorbic acid can instead undergo irreversible hydrolysis to 2,3-diketogulonic acid.
Categories: Diet, Food, and Nutrition, Vitamin C and analoguesVutrisiran
go.drugbank.com/drugs/DB16699ApprovedInvestigational[A249010] The Val30Met variant is the most prevalent among hereditary ATTR patients with polyneuropathy, especially in Portugal, France, Sweden, and Japan. … [A249010] More than 130 TTR mutations have been identified so far,[A249015] but the most common one is the replacement of valine with methionine at position 30 (Val30Met).
Categories: Nucleic Acids, Nucleotides, and NucleosidesHydroxychloroquine
go.drugbank.com/drugs/DB01611ApprovedInvestigationalHydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine]. … [A192132] **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.
Categories: Antiparasitic Products, Insecticides and RepellentsSynonyms: 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline, 7-chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinolineConjunctivitis caused by Chlamydia
go.drugbank.com/conditions/DBCOND0021916Drugs: DemeclocyclineSynonyms: (Viral and chlamydial disease NOS) or (catscratch fever) or (conjunctivitis: [chlamydia] or [trachoma])Daraxonrasib
go.drugbank.com/drugs/DB22308ApprovedInvestigational[L64040,L64041] It is taken by mouth once daily. … [L64039,L64041] Because it targets a broad range of RAS genotypes, it treats tumors with or without an identified RAS mutation and does not require a companion diagnostic test.
UC-781
go.drugbank.com/drugs/DB05871InvestigationalUC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.