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Displaying results 3611 - 3620 of 10000 in total
  1. Target

    Ribose-5-phosphate isomerase B

    go.drugbank.com/bio_entities/BE0002944
    TargetMycobacterium tuberculosis

    Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It has not isomerase activity towards D-allose 6-phosphate.

    Polypeptides: Ribose-5-phosphate isomerase BFunction: ribose-5-phosphate isomerase activity
  2. Target

    2'-5'-oligoadenylate synthase 1

    go.drugbank.com/bio_entities/BE0004585
    TargetHumans

    Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (PubMed:40010341). … Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent

    Polypeptides: 2'-5'-oligoadenylate synthase 1Synonyms: (2-5')oligo(A) synthase 1
  3. Target

    Pyrroline-5-carboxylate reductase 3

    go.drugbank.com/bio_entities/BE0004615
    TargetHumans

    Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs) (PubMed:23024808). … Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H (PubMed:23024808, PubMed:36414121).

    Polypeptides: Pyrroline-5-carboxylate reductase 3Synonyms: Pyrroline-5-carboxylate reductase-like protein
  4. Target

    DAN domain family member 5

    go.drugbank.com/bio_entities/BE0005538
    TargetHumans

    Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its r...

    Polypeptides: DAN domain family member 5
  5. Target

    Ephrin type-A receptor 5

    go.drugbank.com/bio_entities/BE0005587
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the rece...

    Polypeptides: Ephrin type-A receptor 5
  6. Target

    DNA (cytosine-5)-methyltransferase 3B

    go.drugbank.com/bio_entities/BE0010009
    TargetHumans

    Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1.

    Polypeptides: DNA (cytosine-5)-methyltransferase 3BFunction: DNA (cytosine-5-)-methyltransferase activity
  7. Target

    3',5'-cyclic-nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0010168
    TargetRabbit

    Polypeptides: 3',5'-cyclic-nucleotide phosphodiesteraseFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  8. Target

    5'-AMP-activated protein kinase

    go.drugbank.com/bio_entities/BE0011011
    TargetRat

    Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14511394). In response to reduction of intracellular ATP levels, AMPK activa...

    Polypeptides: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2Synonyms: 5'-AMP-activated protein kinase 40 kDa subunit
  9. Target

    Pyrroline-5-carboxylate reductase 2

    go.drugbank.com/bio_entities/BE0000728
    TargetHumans

    Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153

    Polypeptides: Pyrroline-5-carboxylate reductase 2Function: pyrroline-5-carboxylate reductase activity
  10. Target

    Inosine-5'-monophosphate dehydrogenase 1

    go.drugbank.com/bio_entities/BE0000761
    TargetEnzymeHumans

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays

    Polypeptides: Inosine-5'-monophosphate dehydrogenase 1