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Displaying results 3651 - 3660 of 10000 in total
  1. Drug

    Durlobactam

    go.drugbank.com/drugs/DB16704
    ApprovedInvestigational

    It is typically given in combination with [sulbactam] to protect it from degradation by certain serine-beta-lactamases. … [A263306] It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of _Acinetobacter baumannii-calcoaceticus_

    Synonyms: (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL SULFATE, SULFURIC ACID, MONO((2S,5R)-2-(AMINOCARBONYL)-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL) ESTER
  2. Drug

    Dicirenone

    go.drugbank.com/drugs/DB20938
    Experimental

    The usage of the INN stem '-renone' in the name indicates that Dicirenone is a mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonist.

  3. Drug

    Haloprogin

    go.drugbank.com/drugs/DB00793
    ApprovedWithdrawn

    The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. … Haloprogin is no longer available in the United States and has been discontinued.

  4. Drug

    RP-A601

    go.drugbank.com/drugs/DB18339
    Investigational

    RP-A601 is an adeno-associated virus serotype rhesus 10 vector expressing the human galactocerebrosidase (GALC) gene

  5. Drug

    Pentastarch

    go.drugbank.com/drugs/DB09111
    ApprovedWithdrawn

    Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. … It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation.

    Products: HESTAR-200
  6. Drug

    Dofetilide

    go.drugbank.com/drugs/DB00204
    ApprovedInvestigational

    Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation … and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  7. Drug

    Bepotastine

    go.drugbank.com/drugs/DB04890
    Approved

    Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the

  8. Target

    Tumor necrosis factor receptor superfamily member 16

    go.drugbank.com/bio_entities/BE0010540
    TargetHumans

    Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … to the regulation of insulin-dependent glucose uptake (By similarity).

    Polypeptides: Tumor necrosis factor receptor superfamily member 16
  9. Target

    Acetylcholine receptor subunit alpha-type acr-16

    go.drugbank.com/bio_entities/BE0027703
    TargetCaenorhabditis elegans

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity

    Polypeptides: Acetylcholine receptor subunit alpha-type acr-16
  10. Drug

    R-30490

    go.drugbank.com/drugs/DB09179
    Experimental

    R-30490 was found to be the most selective agonist for the mu opioid receptor out of all the fentanyl analogues tested, but it has never been introduced for medical use in humans, although the closely … R-30490 is an opioid related to carfentanil used as an animal tranquilizer.