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3-oxo-5-alpha-steroid 4-dehydrogenase
go.drugbank.com/bio_entities/BE0004887EnzymeTargetHumansAlso able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: 5 alpha-SR2, Steroid 5-alpha-reductase 1Very long chain fatty acid elongase 5
go.drugbank.com/bio_entities/BE0009375EnzymeTargetHumansCatalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- a...
Polypeptides: Very long chain fatty acid elongase 5Synonyms: ELOVL FA elongase 5, ELOVL fatty acid elongase 5Mitogen-activated protein kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0018876TargetHumansSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determ...
Polypeptides: Mitogen-activated protein kinase kinase kinase 5Synonyms: MEKK 5, MEK kinase 5T cell receptor beta variable 5-6
go.drugbank.com/bio_entities/BE0023691TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and ...
Polypeptides: T cell receptor beta variable 5-6NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
go.drugbank.com/bio_entities/BE0000089TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000244TargetHumansIrreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate.
Polypeptides: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
go.drugbank.com/bio_entities/BE0000436TargetHumansCyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has ...
Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AFunction: 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activityBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
go.drugbank.com/bio_entities/BE0003094TargetHumansThe first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate
Polypeptides: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1POU domain, class 5, transcription factor 1
go.drugbank.com/bio_entities/BE0003665TransporterTargetHumansTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3').
Polypeptides: POU domain, class 5, transcription factor 12,3-diketo-5-methylthiopentyl-1-phosphate enolase
go.drugbank.com/bio_entities/BE0003741TargetGeobacillus kaustophilus (strain HTA426)Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
Polypeptides: 2,3-diketo-5-methylthiopentyl-1-phosphate enolaseFunction: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity