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Displaying results 3921 - 3930 of 10000 in total
  1. Drug

    Bemnifosbuvir

    go.drugbank.com/drugs/DB19050
    Investigational

    Bemnifosbuvir is under investigation in clinical trial NCT05629962 (SUNRISE-3: Efficacy and Safety of Bemnifosbuvir in High-risk Outpatients With COVID-19).

    Synonyms: (s)-isopropyl 2-((s)-(((2r,3r,4r,5r)-5-(2-amino-6-(methylamino)-9h-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate, L-alanine, n-((p(s),2'r)-2-amino-2'-deoxy-2'-fluoro-n,2'-dimethyl-p-phenyl-5'-adenylyl)-, 1-methylethyl esterCategories: Heterocyclic Compounds, 2-Ring
  2. Drug

    Udonitrectag

    go.drugbank.com/drugs/DB18013
    Investigational

    Synonyms: (1s,4r,5r,7s)-3, 4-dibenzyl-2-oxo-6, 8-dioxa-3-azabicyclo (3.2.1) octane-7-carboxylic acid, 3, 4-dibenzyl-2-oxo-6, 8-dioxa-3-azabicyclo (3.2.1) octane-7-carboxylic acid, (1s,4r,5r,7s)-Salts: Udonitrectag L-lysine
  3. Drug

    Bivalirudin

    go.drugbank.com/drugs/DB00006
    ApprovedInvestigational

    Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. … Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously.

    Products: ANGIOMAX® POLVO LIOFILIZADO PARA RECONSTRUIR A SOLUCIÓN INYECTABLE (50MG/ML), OBIVADIN 250 MG IV ENJEKSIYON/INFÜZYON IÇIN LIYOFILIZE TOZ, 1 ADET
  4. Drug

    Lidocaine

    go.drugbank.com/drugs/DB00281
    ApprovedInvestigationalVet approved

    Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. … As a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L5930, L5948, F4468].

    Synonyms: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, 2-(Diethylamino)-2',6'-acetoxylidideInternational brands: L-Caine, Lidoject-1
  5. Drug

    Pitavastatin

    go.drugbank.com/drugs/DB08860
    ApprovedInvestigational

    More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid. … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Trolise 4 mg Filmtabletten, ALIPZA 4 MG FILM KAPLI TABLET, 90 ADET
  6. Pathway

    Acylcarnitine 11-{3,4-dimethyl-5-[(1E)-pent-1-en-1-yl]furan-2-yl}undecanoylcarnitine

    smpdb.ca/view/SMP0123498
    Metabolic

    Once inside the cell it undergoes a reaction to form an acyl-CoA derivative called 11-{3,4-dimethyl-5-[(1E)-pent-1-en-1-yl]furan-2-yl}undecanoyl-CoA. … This reaction is facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate acyl groups.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  7. Drug

    Sodium citrate

    go.drugbank.com/drugs/DB09154
    ApprovedInvestigational

    It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. … From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.

    Mixtures: Acd-A, Anticoagulant Citrate Dextrose A ACD-ACategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Fulvestrant

    go.drugbank.com/drugs/DB00947
    ApprovedInvestigational

    Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. … While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative

    Synonyms: (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diolCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  9. Drug

    Fosfomycin

    go.drugbank.com/drugs/DB00828
    ApprovedInvestigational

    [A230348] Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated … [A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.

    Synonyms: L-cis-1,2-epoxypropylphosphonic acid, (2R-cis)-(3-Methyloxiranyl)phosphonic acidProducts: Fosfomycin Infectopharm 40 mg/ml Pulver für ein Konzentrat zur Herstellung einer Infusionslösung, FOSFOMICINA EG
  10. Drug

    Peginterferon alfa-2b

    go.drugbank.com/drugs/DB00022
    ApprovedInvestigational

    Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … When combined together, Peginterferon alfa-2b and [Ribavirin] have been shown to achieve a SVR between 41% for genotype 1 and 75% for genotypes 2-6 after 48 weeks of treatment.

    Synonyms: PEG-IFN-α-2b, Pegylated Interferon α-2bCategories: Compounds used in a research, industrial, or household setting, Hepatitis C