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Displaying results 3941 - 3950 of 10000 in total
  1. Target

    Potassium voltage-gated channel subfamily A member 5

    go.drugbank.com/bio_entities/BE0004717
    TargetHumans

    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. Th...

    Polypeptides: Potassium voltage-gated channel subfamily A member 5
  2. Target

    ATP-binding cassette sub-family G member 5

    go.drugbank.com/bio_entities/BE0004750
    TransporterHumans

    ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356).

    Polypeptides: ATP-binding cassette sub-family G member 5
  3. Target

    Dual specificity mitogen-activated protein kinase kinase 5

    go.drugbank.com/bio_entities/BE0009460
    TargetHumans

    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...

    Polypeptides: Dual specificity mitogen-activated protein kinase kinase 5Synonyms: MEK 5, MAPKK 5
  4. Target

    5'-AMP-activated protein kinase subunit gamma-1

    go.drugbank.com/bio_entities/BE0009988
    TargetHumans

    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ...

    Polypeptides: 5'-AMP-activated protein kinase subunit gamma-1
  5. Drug

    Carisoprodol

    go.drugbank.com/drugs/DB00395
    Approved

    for abuse in addition to a low risk of dependence [L5074]. … In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesSynonyms: (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester, N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate
  6. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase 1

    go.drugbank.com/bio_entities/BE0000539
    TargetEnzymeHumans

    Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Synonyms: Steroid 5-alpha-reductase 1
  7. Target

    High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

    go.drugbank.com/bio_entities/BE0000706
    TargetHumans

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)

    Polypeptides: High affinity 3',5'-cyclic-AMP phosphodiesterase 7AFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  8. Target

    Mitogen-activated protein kinase kinase kinase kinase 5

    go.drugbank.com/bio_entities/BE0009474
    TargetHumans

    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

    Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Synonyms: MEKKK 5, MEK kinase kinase 5
  9. Target

    Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

    go.drugbank.com/bio_entities/BE0014411
    TargetHumans

    Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). … Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity

    Polypeptides: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNFunction: 3'-5' DNA helicase activity
  10. Drug

    Thiamphenicol

    go.drugbank.com/drugs/DB08621
    Investigational

    Products: URFAMYCİN ENJEKTABL FLAKON 500 MG, 1 FLAKON + 1 AMPUL, URFETEM 750 MG FLAKON (1 FLAKON)