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Displaying results 31 - 40 of 605 in total
  1. Target

    Human Retinoid X Receptors (RXRs)

    go.drugbank.com/bio_entities/BE0010096
    TargetHumans

    Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). … Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675).

    Function: DNA-binding transcription factor activity, RNA polymerase II-specific
  2. Target

    Human Vascular Endothelial Growth Factors (VEGFs)

    go.drugbank.com/bio_entities/BE0010103
    TargetHumans

    Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. … Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.

    Polypeptides: Vascular endothelial growth factor B, Vascular endothelial growth factor CSynonyms: VEGF-related factor, Vascular permeability factor
  3. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. … Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity.

    Polypeptides: Splicing factor, proline- and glutamine-richSynonyms: PTB-associated-splicing factor, Polypyrimidine tract-binding protein-associated-splicing factor
  4. Target

    Cleavage and polyadenylation specificity factor subunit 3

    go.drugbank.com/bio_entities/BE0021153
    TargetHumans

    and other factors to bring about cleavage and poly(A) addition. … Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase

    Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunit
  5. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). … The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882).

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPBSynonyms: Basic transcription factor 2 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit
  6. Target

    Lethal factor

    go.drugbank.com/bio_entities/BE0001363
    TargetBacillus anthracis

    In contrast, does not cleave NLRP1 human ortholog (PubMed:19651869). … LF is not toxic by itself and only acts as a lethal factor when associated with protective antigen (PA) to form the lethal toxin (LeTx): PA is required for LF translocation into the host cytosol (PubMed

    Polypeptides: Lethal factor
  7. Target

    Tissue factor

    go.drugbank.com/bio_entities/BE0001178
    TargetHumans

    Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. … TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade

    Polypeptides: Tissue factorSynonyms: Coagulation factor III
  8. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  9. Target

    Nuclear factor erythroid 2-related factor 2

    go.drugbank.com/bio_entities/BE0010121
    TargetHumans

    Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 … Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2

    Polypeptides: Nuclear factor erythroid 2-related factor 2Synonyms: NF-E2-related factor 2, NFE2-related factor 2
  10. Target

    Steroidogenic factor 1

    go.drugbank.com/bio_entities/BE0003359
    TargetHumans

    The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). … Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692

    Polypeptides: Steroidogenic factor 1Synonyms: Fushi tarazu factor homolog 1