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Displaying results 401 - 410 of 1640 in total
  1. Target

    Gastrin-releasing peptide receptor

    go.drugbank.com/bio_entities/BE0012984
    TargetHumans

    Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).

    Polypeptides: Gastrin-releasing peptide receptorSynonyms: GRP-preferring bombesin receptor
  2. Target

    Leukemia inhibitory factor receptor

    go.drugbank.com/bio_entities/BE0013220
    TargetHumans

    Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR … initiated either by binding directly to cytokines, such as OSM or LIF or CTF1, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor

    Polypeptides: Leukemia inhibitory factor receptorSynonyms: LIF receptor
  3. Target

    Nuclear receptor ROR-gamma

    go.drugbank.com/bio_entities/BE0013275
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-gammaSynonyms: Nuclear receptor RZR-gamma, RAR-related orphan receptor C
  4. Target

    Interleukin-17 receptor C

    go.drugbank.com/bio_entities/BE0017016
    TargetHumans

    Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). … Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971).

    Polypeptides: Interleukin-17 receptor CSynonyms: IL-17 receptor C, Interleukin-17 receptor homolog
  5. Target

    Interleukin-17 receptor E

    go.drugbank.com/bio_entities/BE0017393
    TargetHumans

    Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling.

    Polypeptides: Interleukin-17 receptor ESynonyms: IL-17 receptor E
  6. Target

    Lysophosphatidic acid receptor 3

    go.drugbank.com/bio_entities/BE0020529
    TargetHumans

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer.

    Polypeptides: Lysophosphatidic acid receptor 3Synonyms: LPA receptor 3, Lysophosphatidic acid receptor Edg-7
  7. Drug

    Memantine

    go.drugbank.com/drugs/DB01043
    ApprovedInvestigational

    Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD).

    Categories: NMDA Receptor Antagonists, N-methyl-D-aspartate Receptor Antagonist
  8. Drug

    Petrolatum

    go.drugbank.com/drugs/DB11058
    ApprovedInvestigational

    A colloidal system of semisolid hydrocarbons obtained from petroleum. It is used as an ointment base, topical protectant, and lubricant.

  9. Drug

    Entrectinib

    go.drugbank.com/drugs/DB11986
    ApprovedInvestigational

    This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929] … Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.

  10. Target

    5-hydroxytryptamine receptor 4

    go.drugbank.com/bio_entities/BE0000084
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed

    Polypeptides: 5-hydroxytryptamine receptor 4Synonyms: Serotonin receptor 4