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Methoxsalen
go.drugbank.com/drugs/DB00553ApprovedInvestigationalIt is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. … A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: 6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone, 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-oneDemeclocycline
go.drugbank.com/drugs/DB00618ApprovedA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Synonyms: 6-demethyl-7-chlorotetracycline, 7-chloro-6-demethyltetracyclineRimantadine
go.drugbank.com/drugs/DB00478ApprovedAn RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Categories: Influenza A M2 Protein InhibitorSynonyms: alpha-Methyl-1-adamantanemethylamineNalidixic acid
go.drugbank.com/drugs/DB00779ApprovedWithdrawnNalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Synonyms: 1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure, 3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-oneCategories: 4-Quinolones, Heterocyclic Compounds, 2-RingGanirelix
go.drugbank.com/drugs/DB06785ApprovedInvestigational[L43045] The first case of pregnancy achieved after the use of ganirelix in an assisted reproduction program was reported in 1998.[A252195] Ganirelix was first approved by the FDA on July 29, 1999. … Ganirelix is a synthetic decapeptide and a competitive gonadotropin-releasing hormone (GnRH) antagonist. Derived from endogenous GnRH, ganirelix has amino acid substitutions.
Products: ORGALUTRAN® 0.25 MG / 0.5 ML SOLUCION INYECTABLE, ORGALUTRAN 0,25 MG/0.5 ML ENJEKSİYONLUK ÇÖZELTİ, 1 ADETFusidic acid
go.drugbank.com/drugs/DB02703ApprovedInvestigationalIt is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections. … An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.
Mixtures: FUCIDIN H %2 + %1 KREM, 30 G, FUCICORT 20 MG/G + 1 MG/G KREM, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsCholine magnesium trisalicylate
go.drugbank.com/drugs/DB01401ApprovedTrisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28% [A19653, A19654]. … Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug.
Categories: Non COX-2 selective NSAIDSSelenic acid
go.drugbank.com/drugs/DB11068ApprovedIt may be found in over-the-counter daily dietary supplements as a source of [DB11135], an essential trace mineral for human health. … Selenic acid is an organic compound with the chemical formula H2SeO4.
Mixtures: Beta A With Vitamins C and E Plus Selenium, One-A-day Advance Men'sCategories: Compounds used in a research, industrial, or household settingEnmetazobactam
go.drugbank.com/drugs/DB18716ApprovedInvestigational[A263276] The combination product of enmetazobactam and [cefepime] was first approved by the FDA on February 23, 2024, for the treatment of complicated urinary tract infections. … [A263266] Because ESBL enzymes can hydrolyze important antibiotics such as penicillins, broad-spectrum cephalosporins and monobactams, ESBL-producing bacteria poses challenges in the treatment of serious
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: (2s,3s,5r)-3-methyl-3-((3-methyltriazol-3-ium-1-yl)methyl)-4,4,7-trioxo-4^6-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate, 1h-1,2,3-triazolium, 3-(((2s,3s,5r)-2-carboxy-3-methyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-3-yl)methyl)-1-methyl-, inner saltIfenprodil
go.drugbank.com/drugs/DB08954ApprovedInvestigationalWithdrawnBinding at the LBD of the agonists glycine (or D-serine) to the GluN1 subunits and of glutamate to the GluN2 subunits is a regulatory mechanism for channel activation. … [A220118, A220128] One such allosteric regulator is ifenprodil, which was first shown to bind the NMDARs in the 1990s, and specifically to those NMDARs containing the GluN2B subunit.
Categories: Heterocyclic Compounds, 1-Ring