Choline magnesium trisalicylate

DB01401ApprovedSmall molecule

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%...

Mechanism: Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses
Curator reviewed
Primary indication: Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis.Curator reviewed · 8 structured indications
Formula / weight: C₂₆H₂₉MgNO₁₀ · 539.814 g/mol (avg)

Resolves to

Compound

CAS64425-90-7PubChem54682045

Clinical / RWD

RxNorm215799PharmGKBPA164749164

Structure

InChIKeyFQCQGOZEWWPOKI-UHFFFAOYSA-KSMILES[Mg++].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O

Targets

P23219PTGS1P35354PTGS2

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,399Drug interactionsStructured to mechanism, not free text

3Clinical trialsPhase, status and sponsor resolved per trial

8Structured indicationsCondition, population, route and combination as fields, not prose

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Choline magnesium trisalicylate, and which of those have an active Phase 3 trial?

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