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Displaying results 4161 - 4170 of 10000 in total
  1. Drug

    Teriparatide

    go.drugbank.com/drugs/DB06285
    ApprovedInvestigational

    [A251395] First approved in the United States in November 2002 and in Europe in April 2003,[A251400] teriparatide makes the first approved drug in a new category of osteoporosis therapy called anabolic … Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent.[A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH.

    Synonyms: PTH 1-34, PTH (1-34)Products: FORTEO® 250MCG/ML, MEGAPTH-G Teriparatide 20 micrograms / 80 microliters solution for injection
  2. Target

    4-trimethylaminobutyraldehyde dehydrogenase

    go.drugbank.com/bio_entities/BE0000287
    TargetHumans

    Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with ...

    Polypeptides: 4-trimethylaminobutyraldehyde dehydrogenaseFunction: 4-trimethylammoniobutyraldehyde dehydrogenase activity
  3. Target

    Dipeptidyl peptidase 4

    go.drugbank.com/bio_entities/BE0000854
    TargetEnzymeHumans

    Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of ...

    Polypeptides: Dipeptidyl peptidase 4
  4. Target

    Platelet factor 4

    go.drugbank.com/bio_entities/BE0001129
    TargetHumans

    Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule.

    Polypeptides: Platelet factor 4Synonyms: PF-4, C-X-C motif chemokine 4
  5. Target

    Sphingomyelin phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0002300
    TargetHumans

    Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, an...

    Polypeptides: Sphingomyelin phosphodiesterase 4
  6. Target

    Histone deacetylase 4

    go.drugbank.com/bio_entities/BE0003523
    TargetHumans

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation...

    Polypeptides: Histone deacetylase 4
  7. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0004267
    TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseFunction: 4-hydroxyphenylpyruvate dioxygenase activity
  8. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly releas...

    Polypeptides: P2X purinoceptor 4
  9. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed:25163632, PubMed:32327598, Pub...

    Polypeptides: Melanocortin receptor 4
  10. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-densit...

    Polypeptides: Platelet glycoprotein 4Synonyms: PAS-4