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Carboplatin
go.drugbank.com/drugs/DB00958ApprovedInvestigationalCarboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982. … [A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Synonyms: Platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(SP-4-2)Categories: Compounds used in a research, industrial, or household settingTeglarinad chloride
go.drugbank.com/drugs/DB05217InvestigationalGMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity. … Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
Pemivibart
go.drugbank.com/drugs/DB18720InvestigationalPemivibart (Pemgarda) is a human IgG1 monoclonal antibody targeting the SARS-CoV-2 spike protein receptor binding domain. … [L51733] Due to the amino acid substitutions in the Fc region (M435L/N441A), pemivibart has an extended serum half-life.[L51728]
Sulfamerazine
go.drugbank.com/drugs/DB01581ApprovedVet approvedWithdrawnA sulfanilamide that is used as an antibacterial agent.
Synonyms: N(1)-(4-Methyl-2-pyrimidinyl)sulfanilamide, 4-Amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamideEnlicitide
go.drugbank.com/drugs/DB22580ApprovedInvestigationalAbsorption is correspondingly sensitive to food. … It is formulated as enlicitide decanoate alongside the permeation enhancer sodium caprate, which facilitates absorption of the peptide across the gastrointestinal tract, though oral bioavailability remains
Nabiximols
go.drugbank.com/drugs/DB14011InvestigationalIn contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body … Nabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species _Cannabis sativa L._ that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsChromic chloride
go.drugbank.com/drugs/DB09129ApprovedChromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Mixtures: M T E 4 Concentrate Inj, .-4Categories: Compounds used in a research, industrial, or household setting8-chlorotheophylline
go.drugbank.com/drugs/DB14132Experimental8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. … The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous system. 8-chlorotheophylline produces
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 8-chlorotheophylline, 1,3-dimethyl-8-chloroxanthineBelladonna
go.drugbank.com/drugs/DB13913ApprovedBelladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. … The name "belladonna" originates from the Italian words "beautiful woman" and the historical use of herb eye-drops by women to dilate the pupils of the eyes for aesthetic purposes.
Mixtures: ยาเม็ดตกเบ็ด 4., BIOGASTRIN TOZ, 60 GProducts: HE WEI PILLTaurocholic acid
go.drugbank.com/drugs/DB04348ApprovedThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. … It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates