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Displaying results 4311 - 4320 of 10000 in total
  1. Target

    Phosphatidylinositol 4-kinase beta

    go.drugbank.com/bio_entities/BE0009513
    TargetHumans

    Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phospho...

    Polypeptides: Phosphatidylinositol 4-kinase betaSynonyms: PtdIns 4-kinase beta
  2. Target

    Delta-like protein 4

    go.drugbank.com/bio_entities/BE0010485
    TargetHumans

    Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313...

    Polypeptides: Delta-like protein 4Synonyms: Drosophila Delta homolog 4
  3. Target

    Melanoma-associated antigen 4

    go.drugbank.com/bio_entities/BE0010534
    TargetHumans

    Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486)

    Polypeptides: Melanoma-associated antigen 4Synonyms: MAGE-4 antigen
  4. Target

    Alpha-(1,3)-fucosyltransferase 4

    go.drugbank.com/bio_entities/BE0012925
    EnzymeHumans

    Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked … Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:1716630, PubMed

    Polypeptides: Alpha-(1,3)-fucosyltransferase 4Synonyms: Fucosyltransferase 4, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
  5. Target

    Double homeobox protein 4

    go.drugbank.com/bio_entities/BE0020504
    TargetHumans

    Transcription factor that is selectively and transiently expressed in cleavage-stage embryos (PubMed:28459457). Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' (PubMed:28459454, PubMed:28459457, PubMed...

    Polypeptides: Double homeobox protein 4
  6. Drug

    Bicalutamide

    go.drugbank.com/drugs/DB01128
    ApprovedInvestigational

    It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: CASODEX® 150 MG, BICAN ® 50 MG TABLETAS
  7. Drug

    Nimesulide

    go.drugbank.com/drugs/DB04743
    ApprovedInvestigationalWithdrawn

    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.

    Mixtures: ETNA COMBO 100 MG/8 MG TABLET, 14 ADET, NİMES COMBO 100 MG / 8 MG TABLET , 14 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Target

    Potassium channel subfamily K member 6

    go.drugbank.com/bio_entities/BE0000680
    TargetHumans

    K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826, PubMed:40343992, PubMed:41617707). Active in lysosomes where it regulates lysosome numbers and size (P...

    Polypeptides: Potassium channel subfamily K member 6
  9. Target

    Putative mannose-6-phosphate isomerase YvyI

    go.drugbank.com/bio_entities/BE0002646
    TargetBacillus subtilis (strain 168)

    Polypeptides: Putative mannose-6-phosphate isomerase YvyIFunction: mannose-6-phosphate isomerase activity
  10. Target

    Aminoglycoside N(6')-acetyltransferase type 1

    go.drugbank.com/bio_entities/BE0002677
    TargetEnzymeSalmonella enteritidis

    Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin

    Polypeptides: Aminoglycoside N(6')-acetyltransferase type 1Synonyms: AAC(6')-Iy