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Displaying results 4551 - 4560 of 10000 in total
  1. Drug

    Morphine

    go.drugbank.com/drugs/DB00295
    ApprovedInvestigational

    [A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine

    Synonyms: (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol, (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diolCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  2. Drug

    Brevenal

    go.drugbank.com/drugs/DB17865
    Experimental

    Synonyms: 2,4-HEPTADIENAL, 7-((2S,3S,4AS,5AR,6AS,7AR,10S,11R,12AS,14AR,15AS,16S,17AR)-11-(3Z)-3,5-HEXADIEN-1-YLEICOSAHYDRO-10,16-DIHYDROXY-3,10,14A,17A-TETRAMETHYLOXEPINO(3,2-B)PYRANO(2'',3'':6',7')OXEPINO(2',3', :5,6)PYRANO(2,3-F)OXEPIN-2-YL)-3,4-DIMETHYL-, (2E,4E)-
  3. Drug

    Valine-valine-ganciclovir

    go.drugbank.com/drugs/DB17744
    Experimental

    Synonyms: L-valine, l-valyl-, 2-((2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)methoxy)-3-hydroxypropyl ester, Valganciclovir n-valyl impurity
  4. Drug

    Blarcamesine

    go.drugbank.com/drugs/DB05592
    Investigational

    Synonyms: Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanemethanamine, Anavex 2-73Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Quemliclustat

    go.drugbank.com/drugs/DB19160
    Investigational

    Quemliclustat is under investigation in clinical trial NCT05329766 (A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal

    Synonyms: 1h-pyrazolo(3,4-b)pyridin-4-amine, 6-chloro-n-((1s)-1-(2-fluorophenyl)ethyl)-1-(5-o-(hydroxy(phosphonomethyl)phosphinyl)-.beta.-d-ribofuranosyl)-, 2-chloro-n6 -((1s)-1-(2-fluorophenyl)ethyl)-8-aza-1,7- dicarbaadenosine 5'-(trihydrogen 2-carbadiphosphate)Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    SB-218078

    go.drugbank.com/drugs/DB17051
    Experimental

    SB-218078 is a specific inhibitor of CHK1.[A253117]

    Synonyms: 9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2h)-dione, 9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2h)-dione, 9,10,11,12-tetrahydro-
  7. Pathway

    Risperidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126599
    Drug action

    Risperidone has also been said to be an antagonist of alpha-1 (α1), alpha-2 (α2), and histamine (H1) receptors. … 2-fold more potent than 9-hydroxyrisperidone.

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Risperidone · Dopamine · Levodopa +4 more
    Enzymes: Tyrosine 3-monooxygenase, Voltage-dependent calcium channel subunit alpha-2/delta-2
  8. Drug

    2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE

    go.drugbank.com/drugs/DB08743
    Experimental

    Synonyms: 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE
  9. Pathway

    Risperidone Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126598
    Drug action

    Risperidone has also been said to be an antagonist of alpha-1 (α1), alpha-2 (α2), and histamine (H1) receptors. … 2-fold more potent than 9-hydroxyrisperidone.

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Risperidone · Paliperidone · Calcium +3 more
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-2
  10. Drug

    Nitrofurantoin

    go.drugbank.com/drugs/DB00698
    ApprovedInvestigationalVet approved

    [A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] … Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.

    Synonyms: 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedione, N-(5-Nitrofurfurylidene)-1-aminohydantoinCategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-Ring