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Methionine aminopeptidase 2
go.drugbank.com/bio_entities/BE0004075TargetMycobacterium tuberculosisRemoves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylatio...
Polypeptides: Methionine aminopeptidase 2Synonyms: MAP 2Elongation factor 2
go.drugbank.com/bio_entities/BE0004281TargetHumansCatalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly for...
Polypeptides: Elongation factor 2Synonyms: EF-2Trefoil factor 2
go.drugbank.com/bio_entities/BE0004464TargetHumansInhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By simil...
Polypeptides: Trefoil factor 2Exostosin-like 2
go.drugbank.com/bio_entities/BE0004629TargetHumansGlycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfat...
Polypeptides: Exostosin-like 2Synonyms: EXT-related protein 2Urea transporter 2
go.drugbank.com/bio_entities/BE0004691TransporterHumansMediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism
Polypeptides: Urea transporter 2Synonyms: Solute carrier family 14 member 2DNA topoisomerase 2
go.drugbank.com/bio_entities/BE0004951TargetHumansKey decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken st...
Polypeptides: DNA topoisomerase 2-alpha, DNA topoisomerase 2-betaActin, cytoplasmic 2
go.drugbank.com/bio_entities/BE0005013TargetHumansActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing se...
Polypeptides: Actin, cytoplasmic 2Ryanodine receptor 2
go.drugbank.com/bio_entities/BE0005295TargetTransporterHumansIn cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. … Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction.
Polypeptides: Ryanodine receptor 2Synonyms: RYR-2, hRYR-2Sphingosine kinase 2
go.drugbank.com/bio_entities/BE0010025TargetHumansCatalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphing...
Polypeptides: Sphingosine kinase 2Synonyms: SK 2, SPK 2Integrin alpha-2
go.drugbank.com/bio_entities/BE0012664TargetHumansIntegrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Polypeptides: Integrin alpha-2Synonyms: VLA-2 subunit alpha