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Dorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigational[L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and
Mixtures: DORZOLAMIDE AND TIMOLOL STADA EYE DROPS 20MG/5MG, Dorzolamide and TimololCategories: latanoprost and dorzolamide, Antiglaucoma Preparations and MioticsConjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigational[T484] The currently approved product of conjugated estrogens was developed by Wyeth Ayerst and FDA approved in 2003.[L5608] … Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.
Mixtures: Esterified Estrogens and Methyltestosterone, Esterified Estrogens and MethyltestosteroneCategories: Genito Urinary System and Sex Hormones, conjugated estrogens and bazedoxifenePolyethylene glycol
go.drugbank.com/drugs/DB09287ApprovedInvestigationalVet approvedPolyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage. … [A190975] Molecular weights of PEGs vary by time of the polymerization process and the molecular weight represents the weighted average of the individual PEG molecules.
Mixtures: Gavilyte-N, Salinol Sol 160mgCategories: Alimentary Tract and MetabolismBetahistine
go.drugbank.com/drugs/DB06698ApprovedInvestigationalMénière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. … It has a significant impact on both the physical and social functioning of affected individuals.
Synonyms: N-methyl-2-pyridineethanamine, N-methyl-2-(2-pyridinyl)ethanamineProducts: BETAVERT N 24MG, BETAVERT N 16MGIvermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approved[L31453] Ivermectin is mainly used in humans in the treatment of onchocerciasis, but may also be effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis … With the advent of 2020 and the COVID-19 pandemic, ivermectin began garnering notoriety due to its off-label use for the prophylaxis and treatment of COVID-19.
Mixtures: Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbsCategories: Scabicides and Pediculicides, Antiparasitic Products, Insecticides and RepellentsProchlorperazine
go.drugbank.com/drugs/DB00433ApprovedInvestigationalVet approved[label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors. … [L6637] Prochlorperazine was first developed in the 1950s [L6643] and was first approved by the FDA in 1956.
Synonyms: Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine, N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazineProducts: Nu-prochlor Tab 10mg, Nu-prochlor Tab 5mgNalbuphine
go.drugbank.com/drugs/DB00844ApprovedInvestigationalIt appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Synonyms: N-cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriolCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeApoptotic DNA Fragmentation and Tissue Homeostasis
smpdb.ca/view/SMP0063772SignalingICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. … EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis.
Drugs: ZincMetabolism and Physiological Effects of Creatinine
smpdb.ca/view/SMP0123283MetabolicIf not cleared, it can reduce cardiomyocyte contractility and weaken cardiac efficiency, leading to systolic dysfunction and heart failure. … Arginine from the diet is absorbed into systemic circulation and enters hepatocytes through an amino acid transporter, where it undergoes a series of metabolic reactions.
Metabolism and Physiological Effects of Xanthine
smpdb.ca/view/SMP0124865MetabolicThe purines are guanine and adenine. These undergo metabolism in the liver to form xanthine. Adenine forms adenosine through the enzyme purine nucleoside phosphorylase. … Xanthine then enters the blood where it can have detrimental effects on other organs such as the kidney (causing renal failure) and the blood vessel (causing endothelial dysfunction).