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Displaying results 4601 - 4610 of 10000 in total
  1. Drug

    Migalastat

    go.drugbank.com/drugs/DB05018
    ApprovedInvestigational

    Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). … unmet medical need and where a drug is shown to have certain effects that are reasonably likely to predict a clinical benefit to patients.

    Categories: Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones, Heterocyclic Compounds, 1-RingSynonyms: 1-Deoxygalactostatin, 1-Deoxygalactonojirimycin
  2. Target

    Probable peptidoglycan D,D-transpeptidase PenA

    go.drugbank.com/bio_entities/BE0003621
    TargetNeisseria gonorrhoeae

    Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

    Polypeptides: Probable peptidoglycan D,D-transpeptidase PenA
  3. Target

    Uncharacterized MFS-type transporter EfpA

    go.drugbank.com/bio_entities/BE0009715
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Synonyms: Efflux protein A
  4. Indication

    Fever

    go.drugbank.com/conditions/DBCOND0020923
    Drugs: Acetaminophen · Acetylsalicylic acid · Ascorbic acid · Brompheniramine · Caffeine · Chlorpheniramine +20 more
    Synonyms: Has a temperature
  5. Pathway

    Cardiolipin Biosynthesis (Barth Syndrome)

    smpdb.ca/view/SMP0074684
    Disease

    A mutated tafazzin gene disrupts this post-synthetic remodeling and causes Barth syndrome (BTHS), an X-linked human disease (PMID: 16973164). … Last, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor.

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
  6. Indication

    Febrile Illness Acute

    go.drugbank.com/conditions/DBCOND0059951
    Drugs: Acetaminophen
    Synonyms: Has a temperature
  7. Pathway

    Vitamin A Deficiency

    smpdb.ca/view/SMP0125788
    Disease

    Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. … A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
  8. Pathway

    Vitamin A Deficiency

    smpdb.ca/view/SMP0000336
    Disease

    Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. … A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
  9. Drug

    Phenylephrine

    go.drugbank.com/drugs/DB00388
    ApprovedInvestigational

    Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.

    Synonyms: l-(3-Hydroxyphenyl)-N-methylethanolamine, (−)-m-hydroxy-α-(methylaminomethyl)benzyl alcoholInternational brands: AK-Dilate, AK-Nefrin
  10. Target

    ATP-dependent 6-phosphofructokinase, muscle type

    go.drugbank.com/bio_entities/BE0012586
    TargetHumans

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

    Synonyms: PFK-A, 6-phosphofructokinase type A