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Displaying results 4651 - 4660 of 10000 in total
  1. Target

    Beta-lactamase OXA-2

    go.drugbank.com/bio_entities/BE0001778
    TargetSalmonella typhimurium

    This is an oxacillin-hydrolyzing beta-lactamase.

    Polypeptides: Beta-lactamase OXA-2
  2. Target

    Tryptophan--tRNA ligase 2

    go.drugbank.com/bio_entities/BE0001830
    TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

    Catalyzes the formation of 5'adenyl-Trp and tRNA(Trp) but with 5-fold less activity than TrpRS. Increases the solubility of the nitric oxide synthase oxygenase (nos), as well as its affinity for substrate L-arginine and its nitric-oxide ...

    Polypeptides: Tryptophan--tRNA ligase 2Synonyms: TrpRS 2, Tryptophanyl-tRNA synthetase 2
  3. Target

    DNA topoisomerase 2-beta

    go.drugbank.com/bio_entities/BE0002425
    TargetHumans

    Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken st...

    Polypeptides: DNA topoisomerase 2-beta
  4. Target

    Probable butyrate kinase 2

    go.drugbank.com/bio_entities/BE0002643
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Polypeptides: Probable butyrate kinase 2Synonyms: BK 2, Branched-chain carboxylic acid kinase 2
  5. Target

    Thioredoxin reductase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0003388
    TargetEnzymeHumans

    Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling

    Polypeptides: Thioredoxin reductase 2, mitochondrial
  6. Target

    Arylamine N-acetyltransferase 2

    go.drugbank.com/bio_entities/BE0003607
    EnzymeHumans

    Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate sev...

    Polypeptides: Arylamine N-acetyltransferase 2Synonyms: NAT-2, Arylamide acetylase 2
  7. Target

    2-Hydroxyacid oxidase 1

    go.drugbank.com/bio_entities/BE0003766
    TargetEnzymeHumans

    Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549) … Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354

    Polypeptides: 2-Hydroxyacid oxidase 1Function: (S)-2-hydroxy-acid oxidase activity
  8. Target

    2-aminobenzoylacetyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0003865
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ. … Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important

    Polypeptides: 2-aminobenzoylacetyl-CoA thioesterase
  9. Target

    Dihydrofolate reductase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0004001
    TargetHumans

    Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR

    Polypeptides: Dihydrofolate reductase 2, mitochondrial
  10. Target

    Arylacetamide deacetylase-like 2

    go.drugbank.com/bio_entities/BE0004098
    TargetHumans

    Polypeptides: Arylacetamide deacetylase-like 2