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Displaying results 4651 - 4660 of 10000 in total
  1. Target

    SMAD family member 2

    go.drugbank.com/bio_entities/BE0004445
    TargetHumans

    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter regio...

    Polypeptides: SMAD family member 2Synonyms: hMAD-2, SMAD 2
  2. Target

    Adenylate kinase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0004477
    TargetEnzymeHumans

    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of t...

    Polypeptides: Adenylate kinase 2, mitochondrialSynonyms: AK 2, ATP-AMP transphosphorylase 2
  3. Target

    Sterol O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0004608
    TargetEnzymeHumans

    Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:11294643, PubMed:16647063). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643)....

    Polypeptides: Sterol O-acyltransferase 2Synonyms: ACAT-2, Cholesterol acyltransferase 2
  4. Target

    Parathyroid hormone 2 receptor

    go.drugbank.com/bio_entities/BE0004703
    TargetHumans

    This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a si...

    Polypeptides: Parathyroid hormone 2 receptor
  5. Target

    Equilibrative nucleoside transporter 2

    go.drugbank.com/bio_entities/BE0004706
    TransporterTargetHumans

    Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683...

    Polypeptides: Equilibrative nucleoside transporter 2Synonyms: Solute carrier family 29 member 2
  6. Target

    Sodium/glucose cotransporter 2

    go.drugbank.com/bio_entities/BE0004753
    TargetTransporterHumans

    Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Tran...

    Polypeptides: Sodium/glucose cotransporter 2Synonyms: Na(+)/glucose cotransporter 2, Solute carrier family 5 member 2
  7. Target

    Sodium/nucleoside cotransporter 2

    go.drugbank.com/bio_entities/BE0004781
    TransporterHumans

    Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (Pub...

    Polypeptides: Sodium/nucleoside cotransporter 2Synonyms: CNT 2, Na(+)/nucleoside cotransporter 2
  8. Target

    5-hydroxytryptamine 2 receptor

    go.drugbank.com/bio_entities/BE0004881
    TargetHumans

    Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed … phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+

    Synonyms: 5-HT-2Function: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
  9. Target

    5-hydroxytryptamine receptor 2

    go.drugbank.com/bio_entities/BE0004957
    TargetHumans

    Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed … phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+

    Synonyms: 5-HT-2Function: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
  10. Target

    Mitochondrial 2-oxodicarboxylate carrier

    go.drugbank.com/bio_entities/BE0008678
    TransporterHumans

    Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate ( … 2-aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877).

    Polypeptides: Mitochondrial 2-oxodicarboxylate carrierSynonyms: Mitochondrial 2-oxoadipate carrier