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Ustekinumab
go.drugbank.com/drugs/DB05679ApprovedInvestigational[A187349] It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. … Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses.
Categories: Interleukin-23 Antagonist, Interleukin-12 AntagonistProducts: STELARA® 90 MG/ML, STELARA® 45 MG/0.5 MLTryptophan 5-hydroxylase 2
go.drugbank.com/bio_entities/BE0000080EnzymeTargetHumansNeuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin
Polypeptides: Tryptophan 5-hydroxylase 2Synonyms: Tryptophan 5-monooxygenase 2N-acylglucosamine 2-epimerase
go.drugbank.com/bio_entities/BE0000109TargetEnzymeHumansCatalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:10502668, PubMed:12499362, PubMed:9990133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyz...
Polypeptides: N-acylglucosamine 2-epimeraseSynonyms: GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimeraseApoptosis regulator Bcl-2
go.drugbank.com/bio_entities/BE0000246TargetHumansSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368...
Polypeptides: Apoptosis regulator Bcl-2Retinol-binding protein 2
go.drugbank.com/bio_entities/BE0000505CarrierHumansIntracellular transport of retinol
Polypeptides: Retinol-binding protein 2Beta-2 adrenergic receptor
go.drugbank.com/bio_entities/BE0000694TargetHumansG protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater aff...
Polypeptides: Beta-2 adrenergic receptorSynonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptorAcetyl-CoA carboxylase 2
go.drugbank.com/bio_entities/BE0000702TargetHumansCatalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated
Polypeptides: Acetyl-CoA carboxylase 2DNA topoisomerase 2-alpha
go.drugbank.com/bio_entities/BE0000742TargetHumansKey decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken st...
Polypeptides: DNA topoisomerase 2-alphaAngiotensin-converting enzyme 2
go.drugbank.com/bio_entities/BE0000982TargetEnzymeHumansEssential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin...
Polypeptides: Angiotensin-converting enzyme 2Purine nucleoside phosphorylase 2
go.drugbank.com/bio_entities/BE0001556TargetEscherichia coli (strain K12)The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This prot...
Polypeptides: Purine nucleoside phosphorylase 2