Search

Displaying results 471 - 480 of 490 in total
  1. Drug

    Upadacitinib

    go.drugbank.com/drugs/DB15091
    ApprovedInvestigational

    [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada.[L10899,L42540] Upadacitinib is marketed under the brand name RINVOQ for oral administration.

  2. Target

    Tumor necrosis factor ligand superfamily member 13

    go.drugbank.com/bio_entities/BE0010394
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 2
  3. Target

    Ephrin type-B receptor 1

    go.drugbank.com/bio_entities/BE0009441
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the rec...

    Synonyms: Neuronally-expressed EPH-related tyrosine kinase
  4. Target

    Tumor necrosis factor ligand superfamily member 13B

    go.drugbank.com/bio_entities/BE0000999
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humora...

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 1
  5. Target

    Suppressor of tumorigenicity 14 protein

    go.drugbank.com/bio_entities/BE0001656
    TargetHumans

    Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin ...

    Synonyms: Tumor-associated differentially-expressed gene 15 protein
  6. Drug

    Midazolam

    go.drugbank.com/drugs/DB00683
    ApprovedIllicitInvestigational

    Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in th...

  7. Indication

    Blood Transfusion Complications

    go.drugbank.com/conditions/DBCOND0086922
    Drugs: Chlorpheniramine · Methylprednisolone · Triamcinolone
    Synonyms: Transfusion reaction due to excess volume (disorder)
  8. Target

    Protein O-GlcNAcase

    go.drugbank.com/bio_entities/BE0005827
    TargetHumans

    Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, su...

    Synonyms: Meningioma-expressed antigen 5
  9. Drug

    Racementhol

    go.drugbank.com/drugs/DB14123
    ApprovedInvestigational

    Mixtures: Nopen Hot, Nopen CoolProducts: Open Nature Herbal Cough Drops, BestCo Inc.
  10. Target

    Prolyl endopeptidase FAP

    go.drugbank.com/bio_entities/BE0003507
    TargetHumans

    Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma memb...

    Synonyms: Surface-expressed protease