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Larotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … an important role in tumor cell growth and survival.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: VITRAKVI®CÁPSULAS DE 100MG, VITRAKVI 20 MG/ML ORAL ÇÖZELTİ, 2x50 MLMethylene blue
go.drugbank.com/drugs/DB09241ApprovedInvestigationalIts use as an urinary tract antiseptic has also been investigated. … clinical trials to be an inhibitor of Tau protein aggregation.
Mixtures: UR N-C Urinary Antiseptic, Me NaPhos MB Hyo 1Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, MATE 1 InhibitorsInfliximab
go.drugbank.com/drugs/DB00065ApprovedInvestigationalInfliximab is produced by a recombinant cell line cultured by continuous perfusion. … alternative first-line therapies for that disorder [FDA Label].
Synonyms: IMMUNOGLOBULIN G (HUMAN-MOUSE MONOCLONAL CA2 HEAVY CHAIN ANTI-HUMAN TUMOR NECROSIS FACTOR), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL CA2 LIGHT CHAIN, DIMERProducts: INFLECTRA 100MG PLV F E KO, REMICADE 100MG PULV F E KOTremelimumab
go.drugbank.com/drugs/DB11771ApprovedInvestigationalCTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. … [A253717, L43652] Because CTLA-4 is an immune checkpoint that plays a vital role in regulating T cell-mediated immune response, tremelimumab is considered an immune checkpoint inhibitor, which is an emerging
Categories: CTLA-4-directed Blocking AntibodyProducts: Imjudo 300 mg/15 ml İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 adet, Imjudo 25 mg/1.25 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 adetIntermediate conductance calcium-activated potassium channel protein 4
go.drugbank.com/bio_entities/BE0000415TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:9326665 … Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (PubMed:24591580)
Polypeptides: Intermediate conductance calcium-activated potassium channel protein 4Synonyms: SKCa 43-oxo-5-alpha-steroid 4-dehydrogenase 1
go.drugbank.com/bio_entities/BE0000539TargetEnzymeHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Function: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activityATP-binding cassette sub-family C member 4
go.drugbank.com/bio_entities/BE0001188TransporterTargetHumansTransports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid … Transports a wide range of drugs and their metabolites. including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232).
Polypeptides: ATP-binding cassette sub-family C member 4Synonyms: Multidrug resistance-associated protein 44-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase
go.drugbank.com/bio_entities/BE0002977TargetClostridium aminobutyricumThe mechanism of the reaction seems to go through three steps: (1) the FAD-dependent oxidation of 4-hydroxybutyryl-CoA to 4-hydroxycrotonyl-CoA; (2) the hydroxyl group is substituted by a hydride derived … Catalyzes the reversible conversion of 4-hydroxybutyryl-CoA to crotonyl-CoA.
Polypeptides: 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomeraseSynonyms: 4-BUDH4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductaseMitogen-activated protein kinase kinase kinase kinase 4
go.drugbank.com/bio_entities/BE0009473TargetHumansActivator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973).
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 4Synonyms: MEKKK 4, MEK kinase kinase 4