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Displaying results 41 - 50 of 135483 in total
  1. Pathway

    Prednisolone acetate Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174675
    Metabolic

    Metabolites of sildenafil are predicted with biotransformer.

    Drugs: Mesoheme · Prednisolone acetate
  2. Pathway

    Verapamil Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126373
    Drug action

    The inhibition of L-type calcium channels prevents the influx of calcium in vascular smooth muscle myocytes and the heart's cardiomyocytes, which prevents contraction of vascular smooth muscles and heart … Verapamil acts on smooth muscles and cardiac muscles. Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity.

    Drugs: ATP · Verapamil · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  3. Pathway

    Calcium Gluceptate Drug Metabolism Pathway

    smpdb.ca/view/SMP0145439
    Metabolic

    Gadoversetamide passes through the liver and is then excreted from the body mainly through the kidney. … Gadoversetamide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Calcium glucoheptonate
  4. Pathway

    Tetradecyl hydrogen sulfate (ester) Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174856
    Metabolic

    Metabolites of Tetradecyl hydrogen sulfate (ester) are predicted with biotransformer.

    Drugs: Mesoheme · Tetradecyl hydrogen sulfate (ester)
  5. Pathway

    Diltiazem Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126505
    Drug action

    Acting as the main Ca2+ source for contraction in smooth and cardiac muscle, activation of L-type calcium channels allows the influx of calcium ions into the muscles upon depolarization and excitation … This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled

    Drugs: ATP · Diltiazem · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  6. Pathway

    Edetate calcium disodium anhydrous Drug Metabolism

    smpdb.ca/view/SMP0130583
    Metabolic

    Edetate calcium disodium anhydrous passes through the liver and is then excreted from the body mainly through the kidney. … Edetate calcium disodium anhydrous is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Edetate calcium disodium anhydrous
  7. Pathway

    Cinnarizine Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126667
    Drug action

    Cinnarizine is an antihistamine and a calcium channel blocker. Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. … Cinnarizine is a drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting.

    Drugs: ATP · Cinnarizine · Calcium · Magnesium cation
    Enzymes: Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-dependent T-type calcium channel subunit alpha-1H
  8. Pathway

    Methadyl acetate Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0126792
    Drug action

    Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. … Methadyl acetate is a narcotic analgesic with a long onset and duration of action, used to treat narcotic dependence.

    Drugs: ATP · Calcium · Magnesium cation · Methadyl acetate · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  9. Pathway

    Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126292
    Drug action

    Acting as the main Ca2+ source for contraction in smooth and cardiac muscle, activation of L-type calcium channels allows the influx of calcium ions into the muscles upon depolarization and excitation … This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled

    Drugs: Diltiazem · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  10. Pathway

    Flunarizine Calcium Channel Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126303
    Drug action

    Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. … Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel.

    Drugs: ATP · Calcium · Magnesium cation · Flunarizine
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1