Methadyl acetate
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Identification
- Generic Name
- Methadyl acetate
- DrugBank Accession Number
- DB01433
- Background
A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.
- Type
- Small Molecule
- Groups
- Experimental, Illicit
- Structure
- Weight
- Average: 353.4977
Monoisotopic: 353.235479241 - Chemical Formula
- C23H31NO2
- Synonyms
- Acetilmetadol
- Acetylmethadol
- Acetylmethadolum
- Methadyl acetate
- External IDs
- ACSCN-9601
- IDS-NA-004
- NIH-2953
Pharmacology
- Indication
Used mainly in the treatment of narcotic dependence.
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- Pharmacodynamics
Methadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.
- Mechanism of action
Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
Target Actions Organism AMu-type opioid receptor agonistHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
Pathway Category Methadyl Acetate Action Pathway Drug action - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of adverse effects can be increased when Methadyl acetate is combined with 1,2-Benzodiazepine. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Methadyl acetate. Acetophenazine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Methadyl acetate. Aclidinium The risk or severity of adverse effects can be increased when Aclidinium is combined with Methadyl acetate. Agomelatine The risk or severity of CNS depression can be increased when Methadyl acetate is combined with Agomelatine. Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Methadyl acetate. Alimemazine The risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Methadyl acetate. Alloin The therapeutic efficacy of Alloin can be decreased when used in combination with Methadyl acetate. Almotriptan The risk or severity of CNS depression can be increased when Almotriptan is combined with Methadyl acetate. Alosetron The risk or severity of CNS depression can be increased when Alosetron is combined with Methadyl acetate. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Methadyl acetate hydrochloride 3ZD9WAO92T 38821-43-1 UXBPQRGCVJOTNT-UHFFFAOYSA-N
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Diphenylmethanes
- Direct Parent
- Diphenylmethanes
- Alternative Parents
- Aralkylamines / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Amine / Amino acid or derivatives / Aralkylamine / Aromatic homomonocyclic compound / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Diphenylmethane / Hydrocarbon derivative / Monocarboxylic acid or derivatives
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- L59OC40KWJ
- CAS number
- 509-74-0
- InChI Key
- XBMIVRRWGCYBTQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
- IUPAC Name
- 6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate
- SMILES
- CCC(OC(C)=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0015502
- PubChem Compound
- 10517
- PubChem Substance
- 46505532
- ChemSpider
- 10080
- BindingDB
- 50027391
- 6814
- ChEBI
- 135491
- ChEMBL
- CHEMBL170179
- Therapeutic Targets Database
- DAP001137
- PharmGKB
- PA164746889
- Wikipedia
- Acetylmethadol
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source logP 4.27 HANSCH,C ET AL. (1995) - Predicted Properties
Property Value Source Water Solubility 0.00179 mg/mL ALOGPS logP 4.78 ALOGPS logP 4.88 Chemaxon logS -5.3 ALOGPS pKa (Strongest Basic) 9.87 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 29.54 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 117.86 m3·mol-1 Chemaxon Polarizability 40.82 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9965 Blood Brain Barrier + 0.9648 Caco-2 permeable + 0.7459 P-glycoprotein substrate Substrate 0.5822 P-glycoprotein inhibitor I Inhibitor 0.8472 P-glycoprotein inhibitor II Non-inhibitor 0.8897 Renal organic cation transporter Non-inhibitor 0.6473 CYP450 2C9 substrate Non-substrate 0.7976 CYP450 2D6 substrate Non-substrate 0.8641 CYP450 3A4 substrate Substrate 0.6658 CYP450 1A2 substrate Inhibitor 0.5619 CYP450 2C9 inhibitor Non-inhibitor 0.8153 CYP450 2D6 inhibitor Inhibitor 0.7123 CYP450 2C19 inhibitor Non-inhibitor 0.7312 CYP450 3A4 inhibitor Inhibitor 0.5242 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.5811 Ames test Non AMES toxic 0.9016 Carcinogenicity Carcinogens 0.7025 Biodegradation Not ready biodegradable 0.9792 Rat acute toxicity 3.3406 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9706 hERG inhibition (predictor II) Inhibitor 0.7157
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets

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1. DetailsMu-type opioid receptor
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
- Gene Name
- OPRM1
- Uniprot ID
- P35372
- Uniprot Name
- Mu-type opioid receptor
- Molecular Weight
- 44778.855 Da
References
- Mancino MJ, McGaugh J, Feldman Z, Poling J, Oliveto A: Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis. Am J Addict. 2010 Mar-Apr;19(2):169-77. doi: 10.1111/j.1521-0391.2009.00025.x. [Article]
- Walczak SA, Makman MH, Gardner EL: Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9. [Article]
- Wolstein J, Gastpar M, Finkbeiner T, Heinrich C, Heitkamp R, Poehlke T, Scherbaum N: A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction. Pharmacopsychiatry. 2009 Jan;42(1):1-8. doi: 10.1055/s-0028-1083818. Epub 2009 Jan 19. [Article]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]
Drug created at July 24, 2007 20:16 / Updated at February 21, 2021 18:51