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Esmolol Action Pathway (New)
smpdb.ca/view/SMP0126202Drug actionEsmolol is a cardioselective beta 1 blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, esm...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GOxprenolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126219Drug actionOxprenolol is a non-selective beta blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, oxpr...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GPenbutolol Action Pathway (New)
smpdb.ca/view/SMP0126220Drug actionPenbutolol is a non-selective beta blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, penb...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GTimolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126503Drug actionTimolol is a non-selective beta-adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Timolol competes with adrenergic neurotransmitters for binding to beta(1)-adrenergic...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBopindolol Action Pathway (New)
smpdb.ca/view/SMP0126187Drug actionBopindolol is a non-cardioselective beta blocker and the ester prodrug of pinolol. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bro...
Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Methysergide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126851Drug actionMethysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle. Methysergide is a semisynthetic ergot alkaloid ergometrine...
Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Physostigmine Action Pathway
smpdb.ca/view/SMP0125085Drug actionWhen an action potential arrives at the nerve terminal, voltage gated calcium channels open leading to an influx of calcium ions into the neuron.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Pyridostigmine Action Pathway
smpdb.ca/view/SMP0126623Drug actionPyridostigmine is a cholinesterase inhibitor used for the treatment of myasthenia gravis. It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action. T...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FAmbenonium Action Pathway (new)
smpdb.ca/view/SMP0126691Drug actionAmbenonium is a cholinesterase inhibitor used in the treatment of myasthenia gravis, helping to alleviate muscle weakness by stimulating muscle contraction and stimulation. Its mechanism of action is through reversible inhibition of acet...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FMalathion Action Pathway
smpdb.ca/view/SMP0126697Drug actionMalathion is a cholinesterase inhibitor used to treat head lice due to its low toxicity to humans. Malathion is an organophosphate which acts to inhibit acetylcholinesterase activity, it acts by binding to cholinesterase stopping the bre...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1F