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Displaying results 41 - 50 of 198 in total
  1. Pathway

    Alfentanil Action Pathway

    smpdb.ca/view/SMP0000413
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of alfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Alfentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Propoxyphene Action Pathway

    smpdb.ca/view/SMP0000672
    Drug action

    Propoxyphene also causes the closure of voltage-gated calcium channels and opens potassium channels causing the hyperpolarization of the membrane and decreasing neuronal excitability. … Opioids inhibit vasopressin, somatostatin, insulin and glucagon release.

    Drugs: ATP · Norepinephrine · Dextropropoxyphene · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Anileridine Action Pathway

    smpdb.ca/view/SMP0000674
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of anileridine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Anileridine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Methadone Action Pathway

    smpdb.ca/view/SMP0000408
    Drug action

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … Methadone further acts as an antagonist at the NMDA receptor, reducting calcium influx and neuronal excitability.

    Drugs: NADH · ATP · Methadone · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Bupivacaine Action Pathway

    smpdb.ca/view/SMP0000393
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side.

    Drugs: ATP · Bupivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Chloroprocaine Action Pathway

    smpdb.ca/view/SMP0000394
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side.

    Drugs: ATP · Norepinephrine · Dopamine · Chloroprocaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Proparacaine Action Pathway

    smpdb.ca/view/SMP0000403
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side.

    Drugs: ATP · Norepinephrine · Proparacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Remifentanil Action Pathway

    smpdb.ca/view/SMP0000416
    Drug action

    and decrease in cAMP production. … Analgesia, anesthesia, and respiratory depression are a function of remifentanial’s action on these mu-type opioid receptors.

    Drugs: ATP · Norepinephrine · Remifentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Imipramine

    smpdb.ca/view/SMP0000422
    Drug action

    Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake. … This increases the concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of low concentrations of both neurotransmitters found in depression.

    Drugs: NADH · ATP · Norepinephrine · Imipramine · Dopamine · Desipramine +4 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Tramadol Action Action Pathway

    smpdb.ca/view/SMP0000671
    Drug action

    Tramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.

    Drugs: ATP · Tramadol · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1