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Methotrexate Action Pathway (new)
smpdb.ca/view/SMP0126242Drug actionMethotrexate is a chemotherapeutic drug and is a folic acid derivative that inhibits many enzymes involved in nucleotide synthesis.
Levoleucovorin Action Pathway
smpdb.ca/view/SMP0126269Drug actionLevoleucovorin is a folate analog, used to counter the adverse effects of folic acid antagonists. … Folic acid is necessary in order to produce purines, pyrimidines and methionine required for DNA synthesis and replication.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Serine · Glutamic acid · Glycine · Folic acid +1 morePafolacianine Action Pathway
smpdb.ca/view/SMP0126305Drug actionPafolacianine is a folate analogue used for the treatment of ovarian cancer. It targets the folate receptor in cancer cells where they are overexpressed. Pafolacianine binds to the receptor and is absorbed via receptor-mediated endocytos...
Folate Metabolism
smpdb.ca/view/SMP0000053MetabolicMany countries around the world now fortify foods with folic acid to prevent such defects. … From there, dihydrofolate reductase converts folic acid into dihydrofolic acid. Dihydrofolic acid is then created into tetrahydrofolic acid through dihydrofolate reductase.
Pemetrexed Action Pathway
smpdb.ca/view/SMP0126261Drug actionPemetrexed is an antifolate, it contains a pyrrolopyrimidine base within its structure that inhibits DNA synthesis and de novo biosynthesis of nucleotides. Once inside the cell via a folate transporter, it is converted to by folylpolyglu...
Folate Malabsorption, Hereditary
smpdb.ca/view/SMP0000724DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.
Folate Malabsorption, Hereditary
smpdb.ca/view/SMP0125747DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.
Pralatrexate Action Pathway
smpdb.ca/view/SMP0126296Drug actionPralatrexate is a folate analog, used for the treatment of peripheral T-cell lymphoma. Administered intravenously it acts to inhibit dihydrofolate reductase, specifically in cancer cells that have an overexpression of a transporter known...
Triazolam Action Pathway
smpdb.ca/view/SMP0126116Drug actionThese receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Butalbital Action Pathway
smpdb.ca/view/SMP0126149Drug actionButalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. … Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2