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Displaying results 491 - 500 of 2256 in total
  1. Target

    Histamine H2 receptor

    go.drugbank.com/bio_entities/BE0000112
    TargetHumans

    G protein-coupled receptor for histamine, primarily mediating gastric acid secretion.

    Polypeptides: Histamine H2 receptorSynonyms: Gastric receptor I
  2. Target

    Histamine H4 receptor

    go.drugbank.com/bio_entities/BE0000146
    TargetHumans

    G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed … Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (PubMed:39333117).

    Polypeptides: Histamine H4 receptorSynonyms: G protein-coupled receptor 105
  3. Target

    Vasopressin V1a receptor

    go.drugbank.com/bio_entities/BE0000165
    TargetHumans

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

    Polypeptides: Vasopressin V1a receptorSynonyms: Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor
  4. Target

    Prostaglandin D2 receptor

    go.drugbank.com/bio_entities/BE0000296
    TargetHumans

    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. … PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)

    Polypeptides: Prostaglandin D2 receptorSynonyms: PGD receptor, PGD2 receptor
  5. Target

    Adenosine receptor A3

    go.drugbank.com/bio_entities/BE0000354
    TargetHumans

    Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (PubMed:9837869). … In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (By similarity).

    Polypeptides: Adenosine receptor A3Function: G protein-coupled adenosine receptor activity
  6. Target

    Histamine H1 receptor

    go.drugbank.com/bio_entities/BE0000442
    TargetHumans

    G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). … Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules.

    Polypeptides: Histamine H1 receptorFunction: histamine receptor activity
  7. Target

    Ryanodine receptor 1

    go.drugbank.com/bio_entities/BE0000739
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:...

    Polypeptides: Ryanodine receptor 1Synonyms: Type 1 ryanodine receptor, Skeletal muscle ryanodine receptor
  8. Target

    Thromboxane A2 receptor

    go.drugbank.com/bio_entities/BE0000759
    TargetHumans

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. … The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Thromboxane A2 receptorSynonyms: Prostanoid TP receptor
  9. Target

    Vasopressin V1b receptor

    go.drugbank.com/bio_entities/BE0000773
    TargetHumans

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system

    Polypeptides: Vasopressin V1b receptorSynonyms: Vasopressin V3 receptor, Antidiuretic hormone receptor 1b
  10. Target

    Neuropeptide S receptor

    go.drugbank.com/bio_entities/BE0000948
    TargetHumans

    G protein-coupled receptor for neuropeptide S (NPS) (PubMed:15947423, PubMed:16720571, PubMed:16790440). … In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629).

    Polypeptides: Neuropeptide S receptorSynonyms: G protein-coupled receptor 154, G protein-coupled receptor PGR14