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Poly [ADP-ribose] polymerase tankyrase-2
go.drugbank.com/bio_entities/BE0019375TargetHumansActs as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are
Polypeptides: Poly [ADP-ribose] polymerase tankyrase-2Synonyms: TNKS-2, Tankyrase-2Taste receptor type 2 member 4
go.drugbank.com/bio_entities/BE0020472TargetHumansGustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.
Polypeptides: Taste receptor type 2 member 4Serine/threonine-protein kinase pim-2
go.drugbank.com/bio_entities/BE0020600TargetHumansThe stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis.
Polypeptides: Serine/threonine-protein kinase pim-2Neuropeptide Y receptor type 4-2
go.drugbank.com/bio_entities/BE0024014TargetHumansThe rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13
Polypeptides: Neuropeptide Y receptor type 4-2Ipilimumab
go.drugbank.com/drugs/DB06186ApprovedInvestigationalIpilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). … [L12126] Ipilimumab was granted FDA approval on 25 March 2011.[L12126]
Categories: Immunoglobulin G, CTLA-4-directed Blocking AntibodyProducts: YERVOY®5 MG /ML SOLUCION INYECTABLE PARA INFUSION INTRAVENOSA, YERVOY 5 mg/ml concentrate for solution for infusionEculizumab
go.drugbank.com/drugs/DB01257ApprovedInvestigational[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions. … Eculizumab is a monoclonal antibody that targets complement protein C5.
Products: Bekemv 300 mg/30 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 ADET, ELİZARİA 300 MG/30 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedLomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs).
Synonyms: (±)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acidCategories: Heterocyclic Compounds, 2-Ring, 4-QuinolonesNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
go.drugbank.com/bio_entities/BE0000137TargetHumansCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (Probable). Parts of the peri...
Polypeptides: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialSolute carrier family 12 member 2
go.drugbank.com/bio_entities/BE0000281TargetTransporterHumansCation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040...
Polypeptides: Solute carrier family 12 member 2Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2S-adenosylmethionine synthase isoform type-2
go.drugbank.com/bio_entities/BE0000304TargetEnzymeHumansCatalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis ...
Polypeptides: S-adenosylmethionine synthase isoform type-2Synonyms: MAT 2, AdoMet synthase 2